HemeOnc More Drugs Flashcards Preview

HemeOnc More Drugs > HemeOnc More Drugs > Flashcards

Flashcards in HemeOnc More Drugs Deck (17)
Loading flashcards...
0

Drugs for CINV

- Serotonin antagonists (odansetron)
- Corticosteroids (dexamethazone)
- NK1/Substance P Antagonist ("prepitants")
- Benzodiazepines ("zepams")

1

Drugs to overcome myelosuppression

-WBC growth factors
-WBC Colony Stimulating Factors ("stims")
- Sargramostim (GM-CSF)
- Filgrastim (G-CSF)
- Pegilgrastim

2

Drugs to overcome CIA (Chemotx-induced anemia)

-Erythropoiesis-Stimulating Agents (ESAs)
- decrease need for RBC transfusions
- not used much be/c risk of embolism/death
- don't use if intent is cure

3

Serotonin Antagonists

- Used for CINV
- affects acute phase
- Drug: Ondansetron (Zofran)
- blocks 5HT3 receptors (where serotonin binds) in GI tract
- side effects: headache, constipation

4

Corticosteroids

- Used for CINV
- affects delayed phase
- Drug: Dexamethasone
- Side effects: Increased glucose, fluid retention, mood changes, insomnia, increased WBC (steroids)

5

NK1/Substance P Antagonist

- tx for CINV
Drug: "prepitant"
- works in delayed phase
- causes fatigue, nausea, hiccups, constipation, diarrhea, drug interactions

6

Benzodiazepines

- Tx for CINV
- work best in anticipatory phase (pre-chemo)
- Drug: "azepam"
- works by anxiolytic, amnesic
- side effect: sedation

7

WBC Colony Stimulating Factors

-Tx myelosuppression
- Drugs: "stim"s: Sargramostim (GM-CSF), Filgrastim (G-CSF), Pegfilgrastim
- give when risk of febrile neutropenia greater than/equal to 20%
- give 24-72 hrs post chemo

8

What drug(s) cause CNS toxicity?

Cytarabine causes cerebellar toxicity

9

What drugs cause PNS toxicity via cumulative doses?

Cisplatin
Vinca (esp cristine)
Taxanes

10

What drugs cause Autonomic Nervous System toxicity?

Cisplatin
Vinca alkaloids

11

What drugs cause cardiomyopathy?

1) Anthracyclines-> CHF
protect w/ dose of dextrazoxane

2) mitoxantrone

12

What drugs cause arrythmias?

1) Anthracyclines
2) Arsenic
3) Taxanes

13

What drugs cause ischemia?

Pyramidine Analogues
Fluorouracil & Capecitabine

14

purine antagonist

6-mercaptopurine
- pt can have mutation at TPMT locus (homo or hetero)-> blocks major elimination path to 6-methyl mercaptopurine -> more active metabolite of the drug

15

what drugs cause renal toxicity?

cisplatin-> renal tubular damage
--prevention: hydration, lasix, or use carboplatin

HD methotrexate-> high dose (>100) requires rescue with leucovorin and urine alkalinization
--risk factors: renal impairment, cisplatin, NSAIDS
--prevention: hydration, urine alkalinization

16

what drugs cause bladder toxicity/hemorrhagic cystitis?

- typical alkylators ("amides")
- cause direct toxicity
- prevention: hydration, mesna, bladder irrigation