Name this cell
Sézary cell
What is this red cell inclusion indicative of?
Basophilic stippling is indicative of lead poisoning
Name the leukemia and subgroup
What's another name for this subgroup?
- Relatively uncommon
- Characterized by a neoplastic proliferation of megakaryoblasts
Acute myelocytic leukemia M7
What type of non-malignant leukocyte disorder is represented in this smear?
- Deeply stained
- coarse azurophilic granules
- rich in myeloperoxidase
- changes are transient
- frequently associated with severe infection
Toxic granulation
Name the anomaly
- Autosomal-dominant
- hyposegmentation
Pelger-Huët anomaly
Granulocytic WBCs
What WBCs are labeled A?
What WBCs are labeled B?
What WBCs are labeled C?
A: Neutrophilic metamyelocytes
B: Neutrophilic bands
C: Segmented neutrophils
Name the WBC:
Monocyte
Name this leukemia
- Panmyelosis
- 20% of all leukemias in adults
- Clonal myeloid stem cell disorder
- Slight male predominance
- Found mostly in individuals 45-55y.o
- Unusual in Children
- Extramedullary myelopoiesis
- Splenomegaly
Chronic mylogenous leukemia
Identify the anemia
- Hypocellular bone marrow with adipose cells
Aplastic anemia
Name this leukemia and subgroup
- Large cells typically
- Irregular; clefted/indented nucleus
- Heterogeneous chromatin pattern
- Low N:C ratio
- Prominent nucleolus
- Abundant cytoplasm
- Resembles M1
Acute lymphocytic leukemia L2
What erythroid cell is the aroow referring to?
Rubriblast
Name the cell the arrow is pointing to (red cell lineage)
Prorubricyte
Name the leukemia and subgroup
- Primitive leukemic blasts w/ no distinct myeloid morphological features
- Lack reactivity w/ conventional cytochemical stains
- Prognosis poor
Acute myelocytic leukemia M0
Name this stain
What is it used for?
Periodic Acid Schiff stain
Aids in diagnosis of AML M6
Name this stain
What does it stain?
What does it differentiate?
Myeloperoxidase stain
It stains the primary granules of myeloid cells
It differentiates AML from ALL
Name the N/N anemia:
- mild to moderate macrocytic anemia with prominent anisocytosis and poikilocytosis
- autosomal recessive
- bone marroe erythroblasts show megaloblastic maturation
- 1-3% of marrow erythroblasts are binucleated or contain chromatin bridges
Congenital Dyserythropoietic Anemia Type I
Name this red blood cell abnormality:
3-12 UNEVEN spicules
Acanthocytes
Name the immature granulocytic WBC in the center:
Myeloblast
What disorder is the following:
- Ineffective erythropoiesis
Decreased:
- Hgb and Hct
- causing microcytic/hypochromic cells
- MCV
- MCH
- Serum Fe
- % saturation
- Ferritin
Increased:
- RDW- only slightly
- Retics
- TIBC- normal to increased
- FEP
Iron defiiency anemia
What type of WBC is A?
Neutrophilic myelocyte
What is the arrow pointing to?
Auer rod
What inclusion are the arrows pointing to?
- Grey-blue inclusions in the cytoplasm
- spindle-shaped
- aggregated strands of rough ER
- transient
Döhle bodies
What is the inclusion?
What is it associated with?
- Denatured hemoglobin
- crystal violet/ brilliant cresyl blue stain
Heinz bodies
associated with G-6-PD deficiency
What type of non-malignant leukocyte disorder is present in this stain?
- suggests the presence of infection or severe inflammation
- qualitative change in neutrophilia
Toxic vacuoles
Name the WBC
Hypersegmented neutrophils
What type of WBCs are A?
What type are B?
A: Prolymphocytes
B: Lymphocytes
- What type of N/N anemia does this represent?
- What is another name for this anemia?
- What test tells you the identity of this anemia?
- Mild to severe normocytic anemia
- 10-50% of erythroblasts in the marrow are binucleated or multinucleated
- Autosomal recessive
- Most commonly seen form in its "group"
- Reacts with anti-i
- Congenital dyserythropoietic anemia Type II
- HEMPAS- hereditary erythroblasts multinuclearity with a positive acid serum test
- HAM's test
Name the WBC that the left-most arrow is pointing to.
What are 2 alternative names for this type of cell?
Reactive lymphocyte
AKA Turk cells or Downey cells
Name the RBC morphology
What are some disease states that may cause this?
- 10-30 rounded spicules evenly placed over the surface of the RBC
- Associated with uremia
Echinocytes
Causes:
- heart disease,
- bleeding ulcers,
- cancer of the stomach,
- severe burns,
- renal disease,
- liver disease
Name the cell
What stain is positive for this cell?
Hairy Cell leukemia
TRAP stain
