Hematopoiesis Flashcards Preview

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Flashcards in Hematopoiesis Deck (9)
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1
Q

Where pre-natal hematopoiesis occurs

A
  • Yolk sac period: 0 months-3 months gestation, primitive blood cells (especially RBCs) produced in yolk sac
  • Liver/spleen (lesser extent) period: 2 months-7 months gestation
2
Q

Where post-natal hematopoiesis occurs

A
  • At birth, bone marrow is firmly established as site of hematopoiesis
  • As child ages, hematopoiesis becomes more and more localized to the axial skeleton
  • By age 18-20, 90% of hematopoietically active marrow is in vertebrae, pelvis, sternum, ribs and skull
3
Q

Hematopoeisis outside of the bone marrow after birth is

A

abnormal, called extramedullary hematopoiesis

4
Q

Stem cell:

A

the most primitive cell type, capable of self-renewal or differentiation/maturation

5
Q

Progenitor cell:

A

(aka: committed stem cells) limited ability to self-renew, irreversibly committed to differentiate along one or at most 2 lineages

6
Q

Precursor cell:

A

recognizable, maturing cells (ie: that is an immature neutrophil, it will become a neutrophil), capable of cell division, but CANNOT self-renew, give rise to mature, functional cells in the peripheral blood, lymphoid organs and reticuloendothelial system

7
Q

Pluripotential:

A

mother of all blood cells, gives rise to both lymphoid and myeloid elements, CFU-LM (LM=lymphoid/myeloid), can self-renew or commit to becoming a multipotential stem cell

8
Q

Multipotential:

A

CFU-GEMM (GEMM=granulocyte/erythroid/monocyte/megakaryocyte), mother of all myeloid blood cells, some ability to self-renew or they commit to becoming progenitor cells

9
Q

Myeloid progenitors:

A
  • CFU-GM (granulocytes/macrophage)
  • CFU-G (granulocyte),
  • CFU-M (monocyte),
  • CFU-E (erythroid),
  • CFU-Meg (megakaryocyte),
  • CFU-Eo (Eosinophil),
  • CFU-Baso (Basophil),
  • BFU-E (Burst forming unit, gives rise to CFU-E)