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Flashcards in Hematology Lecture Final Deck (122)
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1

The SBB stain is the most sensitive stain for what precursor cells?

Granulocytic precursors

2

The SBB staining pattern parallels what other stain?

Myeloperoxidase

3

TdT, terminal deoxynucleotidyl transferase, is found in 90% of what type of leukemia?

Acute lymphoblastic leukemia

4

What does SBB stain?

Phospholipids, neutral fats, and sterols

5

The _______ stain is more specific than the _______ stain.

The Myeloperoxidase stain is more specific than the Sudan black B stain

6

The ________ stain is more sensitive than the _______ stain.

The Sudan black B stain is more sensitive than the Myeloperoxidase stain.

7

What chromosome abnormality is found in Precursor B-cell ALL?

t(1;19)

8

A positive nonspecific esterase stain indicates what type of differentiation?

Monocytic

9

A strong PAS reaction supports the diagnosis of ________

Erythroleukemia

10

The acid phosphatase/tartrate resistant stain is used for making diagnosis of?

Harry Cell Leukemia

11

Cytoplasmic marker studies are useful in assessing cell lineage in?

Acute Lymphoblastic Leukemia

12

What is the classification of anemia in CLL?

Normocytic/normochromic

13

In leukemia, the presence of predominantly mature malignant cells is classified as _________

Chronic

14

Diagnosis of CLL can be confirmed immunologically by the use of monoclonal antibodies that detect _____________ antigens

Cluster differentiation (CD)

15

Most patients are diagnosis in which phase of CML?

Chronic

16

Acute erythroleukemia is characterized by an abnormal proliferation of what precursors?

erythroid and myeloid

17

In CML, transformation to a more critical phase is evident by the appearance of which cells?

Blasts

18

The morphology of acute lymphoblastic leukemia is evaluated on what type of smear?

Bone marrow aspirate

19

On Romanowsky-stained smears, how do Auer rods appear?

Pink or purple staining rods

20

Cytochemical stains were performed on bone marrow smears from an acute leukemia patient. All blasts were TdT negative. The majority of the blasts showed varying amounts of SBB positivity. 50% of them stained positive for NSE. What type of leukemia is indicated?

Acute myelomonocytic leukemia

21

True or False:

Age of the patient, nuclear chromtin pattern, and presence of nucleoli can all be used to differentiate CLL from ALL.

True

22

True or False:

Chronic leukemias are found primarily in children

False

23

What is the chromosomal abnormality in CML?

t(9;22)

24

What is the most common chromosomal abnormality in B-CLL?

Trisomy 12

25

What are required hematologic findings for a diagnosis of CLL?

  • 10,000/uL lymphocytes in the peripheral blood
  • 30% lymphocytosis in the bone marrow

26

What type of leukemia is associated with these cells?

B-cell Acute Lymphocytic Leukemia L3

27

Identify the leukemia

Chronic lymphocytic leukemia

28

What is the only curative treatment for CML?

Hematopoetic stem cell transplant

29

The prominent laboratory feature representative of CML is?

Leukocytosis with a left shift

30

Which FAB classification of ALL represents a heterogeneous population and is morphologically similar to AML M1?

ALL L2