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Flashcards in Hematology Deck (17)
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1

sickle cell anemia - labs

sickled cells on peripheral smear
Hgb S on hemoglobin electrophoresis

2

Thalassemia - labs

microcytic anemia with normal/ increased serum Fe or no response to Fe tx

3

G6PD Deficiency - labs

Episodic hemolytic anemia - sulfa drugs, fava beans, infections

4

Hereditary Spherocytosis - labs

microspherocytes, coombs negative, + osmotoic fragility test

5

Autoimmune hemolytic anemia - labs

microspherocytes, Coombs +

6

TTP - labs

normal coags
Pentad: thromobyctopenia, hemolytic anemia, kidney damage, neurolgic symptoms, fever

7

HUS - labs

normal coags
Triad: thrombocytopenia, hemolytic anemia & kidney disease
MC in children, kidney involvement

8

DIC - labs

abnormal coags (prolonged PT & PTT)

9

paroxysmal nocturnal hemoglobinuria - labs

dark urine, worse in the morning

10

Von Willebrand Disease

ineffective platelet adhesion
petechiae
decreased vWF levels, prolonged PTT (worse with aspirin)
decreased ristocetin activity test - gold standard

11

Hodgkin Disease (lymphoma)

bimodal - 20yo and >50yo
reed sternberg cells
B cell proliferation
associated w/ EBV
painless lymphadenopathy
highly curable

12

Non Hodgkin Lymphoma

MC > 50 yo
Peripheral lymph nodes MC - local painless lymphadenopathy
Burkitt lympohma
unpredictable course

13

Multiple Myeloma (plasmacytoma)

proliferation of single clone of plasma cells
elderly >65, african american men MC
bones break - hypercalcemia
urine protein - bence-jones proteins
CBC - rouleaux fomration
Skull - punched out lytic lesions
bone marrow - plasmocytosis
Autologous stem cell transplant - definitive tx

14

ALL

MC childhood malignancy (3-7yo)
hepatosplenomegaly, fever, CNS symptoms
Bone marrow hypercellular with >20% blasts
PO chemo, combination

15

CLL(b cell)

B cell clonal malignancy
MC >50y caucasian males
peripheral smear - well differentiated lymphocytes with scattered smudge cells

16

AML

MC acute form of leukemia in adults
pancytopenia
leukostasis
gingival infiltration
bone marrow - auer rods & >20% blasts
tumor lysis syndrome

17

CML

blastic crisis, splenomegaly
+philadelphia chromosome
increased WBC counts
PO chemo + imatinib