Flashcards in Hematology Deck (63)
What is the kids leukemia?
What is the median age of onset of AML?
What are the most common pathogens in patients with leukemia induced neutropenia?
Gram-negatives and fungi
Young patient with lymphadenopathy, hepatosplenomegaly and chronic fatigue, what do you suspect?
What type of blood dyscrasia causes Auer rods to be seen in the cell cytoplasm?
What is the definitive diagnostic finding for ALL?
terminal deoxynucleotidyl transferase
What additional treatment is commonly needed in acute leukemia to combat a side effect of chemotherapy?
Allopurinol and diuretics d/t increased uric acid blood levels
What are the greatest indicators of prognosis for the acute leukemias?
WBC count and age at diagnosis
What are the cure rates for ALL and AML with current therapies?
> 50% with ALL, > 70% at < 60 years with AML
Which leukemia is a malignancy of the B lymphocytes?
What is the most prevalent leukemia?
What are the typical characteristics of a CLL patient?
median age 65, twice as common in men as women
50 yo F presents with episodes of excessive sweating, low-grade fevers, anorexia, weight loss and chronic fatigue. Which leukemia do you suspect?
What are the three phases of CML?
chronic, accelerated and blast crisis - you need to catch it before stage 3 for prognosis
Which leukemia has a mild course but is resistant to cure? Average survival?
CLL - median survival 6 years or 10-15 with stage 0-1
Which blood dyscrasia should be suspected with isolated lymphocytosis and leukocytosis greater than 20k?
Which blood dyscrasia should be suspected with keukocytosis with median WBC count of 150k?
What is the new test that has replaced the test for the philadelphia chromosome?
Which blood dyscrasia shows smudge cells on peripheral smear?
What is the standard therapy of choice in CML?
imatinib mexylate (gleevee) then likely bone marrow transplant
Pt presents with fatigue, anemia, elevated corrected reticulocyte count, elevated indirect bilirubin and LDH. What work up is needed?
work up for hemolysis
What is the typical cause of sideroblastic anemia?
What is the work up for microcytic anemia?
Lead levels, TIBC and FeSat, hemoglobin electrophoresis for Hgb A2 and F will be abnormal in thalassemia
What should you think of if Burr cells are seen on smear? (4)
Peptic ulcer, cancer of stomach, Uremia, Vitamin K deficiency
What should you think of if Spur cells are seen on smear (1)?
What should you think of if stomatocytes are seen on smear (1)?
alcoholic liver disease
What should you think of if shistocytes (helmet cells) are seen on smear?
TTP, DIC, glomerulonephritis, heart valve, burns
If you see bite cells on smear, what should you think?
If you see basophilic stippling on smear, what should you think?