HD46-7 Diabetes Flashcards Preview

Stage 3 Human Diseases > HD46-7 Diabetes > Flashcards

Flashcards in HD46-7 Diabetes Deck (56)
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1

Why is blood glucose raised in type 1 diabetes?

• Due to autoimmune destruction of beta cells= insulin

2

Why is blood glucose raised in type 2 diabetes?

• Due to combination of insulin resistance and relative insulin lack

3

what are the types of diabetes?

1, 2 , gestational, or secondary to other condition

4

Uses of measurements of glycated Haemoglobin:

Diagnosis can also be made by HbA1c level of over 48mmol/mol
This test is also used over a few weeks to measure success of tx.

5

Does this raise or lower blood glucose?
food

raise

6

Does this raise or lower blood glucose?
starvation

lower

7

Does this raise or lower blood glucose?
glucagon

raise

8

Does this raise or lower blood glucose?
adrenaline

raise

9

Does this raise or lower blood glucose?
cortisol

raise

10

Does this raise or lower blood glucose?
growth hormone

raise

11

Does this raise or lower blood glucose?
Insulin

lowers

12

Does this raise or lower blood glucose?
anti-diabetic drugs

lowers

13

Does this raise or lower blood glucose?
illness

raises

14

Does this raise or lower blood glucose?
stress

raises

15

Does this raise or lower blood glucose?
excersize

lowers

16

Which 4 hormones increase glucose levels?

1. Glucagon – made by a alpha cell of islets of Langerhann in pancreas = make
2. Adrenaline
3. GH
4. Cortisol – hydrocortisone steroid hormone

17

is it a secretagogue or sensitzer, or does it delay carbohydrate absortion:
sulphoylureas

secretagogue
(can cause hypoglycaemia and weight gain)

18

is it a secretagogue or sensitzer, or does it delay carbohydrate absortion:
gliclazide

secretagogue
(a type of sulphonyureas )
(can cause hypoglycaemia and weight gain)

19

is it a secretagogue or sensitzer, or does it delay carbohydrate absortion:
DPP4 inhibitors

secretagogue (also described as having combined actions)
-liptin= DPP4 inhibitor

20

is it a secretagogue or sensitzer, or does it delay carbohydrate absortion:
sitagliptin

secretagogue (also described as having combined actions)
-liptin= DPP4 inhibitor

21

is it a secretagogue or sensitzer, or does it delay carbohydrate absortion:
vildagliptin

secretagogue (also described as having combined actions)
-liptin= DPP4 inhibitor

22

is it a secretagogue or sensitzer, or does it delay carbohydrate absortion:
GLP-1 binder

tide= GLP-1 binder
secretagogue
(also described as having combined actions:stimulates insulin secretion, reduced glucagon secretion and delayed gastric emptying. = prevent weight gain )

23

is it a secretagogue or sensitzer, or does it delay carbohydrate absortion:
exanetide

-tide= GLP-1 binder
secretagogue
(also described as having combined actions:stimulates insulin secretion, reduced glucagon secretion and delayed gastric emptying. = prevent weight gain )

24

is it a secretagogue or sensitzer, or does it delay carbohydrate absortion:
liraglutide

tide= GLP-1 binder
secretagogue
(also described as having combined actions:stimulates insulin secretion, reduced glucagon secretion and delayed gastric emptying. = prevent weight gain )

25

is it a secretagogue or sensitzer, or does it delay carbohydrate absortion:
biguanides

biguanides (metformin)
sensitiser

26

is it a secretagogue or sensitzer, or does it delay carbohydrate absortion:
metformin

biguanides (metformin)
sensitiser

27

is it a secretagogue or sensitzer, or does it delay carbohydrate absortion:
thiazolidines

thiozolidinediones ("glitazones"e.g. pioglitazone
sensitiser

28

is it a secretagogue or sensitzer, or does it delay carbohydrate absortion:
pioglitazone

thiozolidinediones ("glitazones"e.g. pioglitazone
sensitiser

29

it a secretagogue or sensitzer, or does it delay carbohydrate absortion:
acarbose

3. Delayed carbohydrate absorption:
Acarbose: alpha-glucosidase inhibitor (rarely used= wind)

30

it a secretagogue or sensitzer, or does it delay carbohydrate absortion:
guar gum

delayed carb absorption