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Flashcards in Halothane Deck (14)
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1

Halothane boiling point

50.2 C

2

Halothane saturated vapor pressure

243 mmHg

3

Halothane MAC

0.74 vol%

4

Halothane blood/gas coefficient

2.3

5

Halothane brain/blood coefficient

2.9

6

Halothane muscle/blood coefficient

3.5

7

Halothane fat/blood coefficient

60

8

Halothane Pulmonary effects

Medium(but more than N2O) decrease in tidal volume and increase in end tidal CO2 (same as sevo).
Respiratory depressant.
Alveolar hypoventilation causes arterial hypercapnia- rapid & shallow breaths.
Profoundly blunts ventilatory response to hypercapnia.
Subanesthetic concentrations abolish response to hypoxemia.
Increases arterial-alveolar gradient.
Unrecognized apnea during deep halothane anesthesia can be catastrophic.
Surgical stimulation increases respiratory drive and counteracts some respiratory depressant effects of halothane.

9

Halothane CV effects

Dose dependent arterial hypotension, causing increase CVP (significant depressant of myocardial contractility)-- dose dependent decrease in cardiac output = decreased MVO2
SVR stays intact
Most amount of negative inotropic effect (inhibits calcium influx through slow channel, decreases availability of calcium for activation of contraction * decreased storage)
No activation of sympathetic nervous system
Decreases coronary blood flow and vascular resistance
Common to see slow AV junctional/dissociation rhythms

10

Halothane recommendations with epinephrine

Decreases ectopy threshold- recommended that no more than 100 mcg of epi be injected in less than 10 minutes and no more than 5mcg/kg during injection process -- WORSE WITH HYPERCAPNIA (children less sensitive)

11

Halothane burst suppression at what MAC

3.5

12

Halothane hepatic metabolism effects

Bromide metabolism can cause somnolence & confusion if >6 MeQ/L, hepatitis due to reductive metabolism in presence of hepatocyte hypoxia

13

Halothane liver:blood coefficient

2.1

14

Halothane kidney:blood coefficient

1.2