Haemopoiesis Flashcards Preview

Metabolism, Endocrinology and Haematology > Haemopoiesis > Flashcards

Flashcards in Haemopoiesis Deck (6)
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1
Q

Where are the main sites of haemopoiesis

A

In the bone marrow of:

Pelvis, Sternum, Skull, Ribs and Vertebrae

2
Q

What are the five major lineage pathways that arise from haemopoietic stem cells

A

Thrombopoiesis

Granulopoiesis

Monocytopoiesis

Lymphopoiesis

Erthyropoiesis

3
Q

What is thrombopoiesis

A

Formation of platelets involved in blot formation

Platelets are essentially membrane bound fragments of cytoplasm that bud off of megakaryocytes.

Megakaryocyte formation is driven by thrombopoietin

4
Q

What is granulopoiesis and what cells does it produce

A

Process to produce granulocytes- basophils, neutrophils, eosinophils

Myeloblast cells differentiate into these cell types

5
Q

What is monocytopoiesis

A

The production of monocytes from myeloblast cells

Monocytes then differentiate into macrophages or dendritic cells when they enter tissues

6
Q

What is lymphopoiesis and explain how the two types of lymphocytes are formed

A

Production of B and T lymphocytes from common lymphoid progenitor cells

B lymphocyte production begins in the foetal liver and bone marrow with immunoglobulin genes rearranging during development to allow from production of antibodies

T lymphocyte production begins in the foetal liver and then the T lymphocyte progenitors migrate to the thymus early in gestation