Glycolysis Flashcards Preview

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Flashcards in Glycolysis Deck (14)
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1
Q

____ pathway which converts glucose to pyruvate

A

Glycolysis

2
Q

Hexokinase: muscles :: _____ : liver

A

glucokinase

not inhibited by its product G6P

3
Q

The first committed step in glycolysis ____. Also, name the enzyme.

A

phosphorylation of F6P to F1,6,P. PFK1

4
Q

The net result of glycolysis (include product and ATP used)

A

2 pyruvate, use of 2 ATP

5
Q

The active site in the oxidation of G3P to 1,3 BPG contains ___ (amino acid)

A

Cysteine

6
Q

This enzyme drives formation of pyruvate from PEP. Also very active in the fed state.

A

Pyruvate kinase

7
Q

In the RBC, 1,3 BPG can be converted to 2,3 BPG. Increase in its concentration can ____ (increase, decrease) the affinity of Hb to O2

A

decrease

8
Q

In terms of Km for glucose, hexokinase ___ glucokinase (greater, lesser, same)

A

Km: hexokinase is lesser than glucokinase

Affinity: hexokinase is greater than glucokinase

9
Q

The two major regulatory enzymes in the skeletal muscle

A

Hexokinase and PFK1

10
Q

The two major regulatory enzyme in the liver

A

Glucokinase, PFK 1 activated by F2,6P, and pyruvate kinase

11
Q

Pyruvate kinase is activated by ____ in the fed state and inhibited by _____ in the fasting state.

A

Activated by: F1,6BP

Inbibited by alanine and phosphorylation in the liver

12
Q

What are the fates of pyruvate during hypoxia and alcohol ingestion

A

lactate formation (lactate dehydrogenase)

13
Q

Aside from lactate formation, pyruvate can be converted to ____ and ____

A

acetyl-CoA (pyruvate dehydrogenase) and Oxaloacetate (pyruvate carboxylase)

14
Q

The cytosolic DHAP is reduced to G3P by NADH in this shuttle system

A

Glycerol Phosphate Shunt

1 NADH = 1.5 ATP