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Flashcards in Gluconeogenesis Deck (17)
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1

Where does gluconeogenesis occur?

Liver and some in the kidney

2

How does gluconeogenesis occur?

Pyruvate can be converted to G6P which is turned back into glucose with G6-phosphatase as the key enzyme that
will allow for gluconeogenesis

3

What occurs as a result of low blood glucose?

Stimulation of gluconeogenesis

4

What are the major gluconeogenic precusors?

Lactate
Gluconeogenic AAs
Glycerol

5

Where does glycolysis occur?

In all cells

6

What is the core cycle?

Converts lactate into glucose

7

What is the alanine cycle?

Converts alanine into glucose

8

What is fructolysis?

The conversion of fructose to lactate

9

What does glycogenesis from precursors require?

ATP

10

What is the function of pyruvate carboxylase?

Converts pyruvate into oxaloacetate

11

What does Pyurvate Carboxylase genetic deficiency cause?

The lack of PC enzyme activity causes the accumulation of pyruvate in the plasma, which is subsequently converted into lactate by the enzyme lactate dehydrogenase, causing an elevated plasma concentration of lactic acid.

12

What does Glucose-6-phosphatase deficiency cause?


It is characterized by poor tolerance to fasting, growth retardation and hepatomegaly resulting from accumulation of glycogen and fat in the liver (enlarged), elevated serum uric acid and elevated serum lactate.

13

What enzyme allow for the reaction G6P -> Glucose?

Glucose-6-phosphatase

14

What enzyme allows for the reaction Fructose-1,6-bisphosphate -> Fructose-6-Phosphate?

Fructose-1,6-bisphosphatase

15

What enzyme allows for the reaction Pyruvate -> Phosphoenolpyruvate?

PEPCK

16

What can ethanol metabolism cause?

Hypoglycemia

17

How can ethanol metabolism cause hypoglycemia?

High NADH opposes gluconeogenesis.
Increased NADH leads to increase lactate formation -> less precursors available for gluconeogenesis

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