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Flashcards in Gastrointestinal Drugs Deck (40)
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1
Q

This antacid reacts rapidly with HCL

A

Sodium Bicarbonate

2
Q

Side effects of Aluminum or Magnesium hydroxide

A

Aluminum - Constipation

Magnesium - Diarrhea

3
Q

What antacid can lead to hypercalcemia, renal insufficiency and metabolic alkalosis

A

Calcium carbonate

4
Q

What are the histamine blockers that go through first pass effect

A

Cimentidine
Ranitidine
Famotidine

5
Q

Clinical use of H2 blocker

A

GERD
Peptic Ulcer disease
Non ulcer dyapepsia
Prevention of bleeding

6
Q

AE of cimentidine

A

Mental status change
Gynecomastia
Galactorrhea
Impotence

7
Q

Treatment of acid peptic disease

A

Proton Pump Inhibitors

8
Q

When do you administers PPI o

A

On an empty stomach

9
Q

MoA of PPI

A

Inhibit both acid fasting and meal stimulated secretion

10
Q

AE of PPI

A

CAR infection
Nosocomial pneumonia
Enteric infection

11
Q

What PPI may inhibit warfarin,diazepam and phenytoin

A

Omeprazole

12
Q

This ppi enhances clearance of theophylline

A

Lansoprazole

13
Q

Has limited solubility, breaking down into sucrose sulfate and aluminum salt

A

Sucralfate

14
Q

Used for prevention of traveler’s diarrhea

A

Bismuth compounds

15
Q

What is now used for acute large bowel distention or oglivie’s syndrome

A

Neostigmine

16
Q

Potent anti nausea and anti emetic action

A

Dopamine antagonist

Metoclopromide
Domperidone

17
Q

This drug has extrapyramidal effects

A

Metoclopromide

18
Q

Bulk forming laxative

A

Psyllium
Methycellulose
Polycarbophil

19
Q

AE of bulk forming stool

A

Bloating

Flatus

20
Q

Stool softeners

A

Docusate
Glycerin suppository
Mineral oil

21
Q

AE of stool softeners

A

Impair absorption of ADEK

22
Q

Commonly used osmotic laxative

A

Magnesium hydroxide

Milk of magnesia

23
Q

Sugars that prevent or treat chronic constipation

A

Sorbitol

Lactulose

24
Q

Given before endoscopy

A

Balanced PEG

25
Q

These drugs may decrease diarrhea by excess fecal bile acids

A

Colestyramine
Colestipol
Colesevelam

26
Q

AE of somatostatin

A

Stearrothrea

27
Q

Serotonin receptor antagonist activate afferwnt pain sensation

A

Alosetron

28
Q

Used for severe IBS with predominant diarrhea

A

Alosetron

29
Q

Given with severe ibs with predominant constipation

A

Tegaserod

30
Q

What is the pathway used by antiemetic agents

A

Nucleus tractus solitarius

31
Q

Clinical usage of serotonin antagonist

A

Chemotheraphy induced nausea and vomting

Post operative and radiation nausea and vomiting

32
Q

This anti emetic drugs can cross the bbb

A

Neurokinin antagonist

Apreripant
Fosaprepitant

33
Q

Antipsychotic drug that is potent antiemetic and sedative

A

Phenothiazines

34
Q

Central dopaminergic blockade

A

Droperidol

35
Q

Treatment of emesis due to chemotherapy

A

Diphenhydramine

36
Q

Best agent used for the prevention of motion sickness

A

Hyoscine

Scopolamine

37
Q

Drug used to reduced anticipatory vomiting by anxiety

A

Lorazepam

Diazepam

38
Q

Mesalamine compounds

A

Rowasa or canasa (suppositories)

39
Q

Given for crohn’s disease

Moderate to severe active inflammatory bowel disease

A

glucocorticoid

Budesonide

40
Q

Severe crohn’s disease

Anti integrin therapy

A

Natalizumab