G-protein-linked receptors indirectly targeted by drugs Flashcards Preview

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Flashcards in G-protein-linked receptors indirectly targeted by drugs Deck (5)
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1
Q

Agonist via increasing dopamine at receptors D1 and D2 (possibly D3 and D4)

A

Stimulant at DAT and VMAT2 for improvement of ADHD. Antidepressant at DAT and NET for antidepressant and ADHD. MAO inhibitor reduces dopamine metabolism for antidepressant.

2
Q

Agonist via increasing serotonin at all serotonin receptors 5HT1A, 5HT2A; possibly 5HT2C, 5HT6, 5HT7

A

Antidepressant at SERT for depression and anxiety. MAO inhibitor for depression.

3
Q

Agonist via increasing norepinephrine at NET Beta2 and possibly Alpha2

A

Antidepressant and neuropathic pain at NET for depression, ADHD, and chronic pain when combined with SERT inhibition. MAO inhibitor reducing norepinephrine metabolism for depression.

4
Q

Agonist via increasing GABA at GABAa and GABAb.

A

Anticonvulsant at GABA GAT1 transporter for anticonvulsant; possibly anxiolytic, for chronic pain, for slow-wave sleep.

5
Q

Agonist via increasing acetylcholine at receptors M1 (possibly M2-M5)

A

Acetylcholinesterase inhibitor reducing acetylcholine metabolism for slowing Alzheimer’s disease progression.