Fiser Chapter 6 ANTIBIOTICS Flashcards Preview

ABSITE > Fiser Chapter 6 ANTIBIOTICS > Flashcards

Flashcards in Fiser Chapter 6 ANTIBIOTICS Deck (53)
Loading flashcards...
1

Betadine

An iodophor
Good for GPCs and GNRs
Not for fungi

2

Chlorhexidine gluconate

e.g. Hibiclens
Good for GPCs, GNRs, and fungi

3

Quinolone MoA

DNA gyrase/helicase inhibitors

4

Rifampin MoA

RNA polymerase inhibitor

5

PCN MoA

Cell wall synthesis inhibitor

6

Vanc MoA

cell wall synthesis inhibitor

7

Cephalosporin MoA

Cell wall synthesis inhibitor

8

Carbapenem MoA

Cell wall synthesis inhibitor

9

Monobactam (aztreonam) MoA

Cell wall synthesis inhibitor

10

Tetracycline MoA

30s ribosome and protein synthesis inhibitor

11

Aminoglycoside MoA

e.g. Tobramycin, Gentamicin
30s ribosome and protein synthesis inhibitor

12

Linezolid MoA

30s ribosome and protein synthesis inhibitor

13

Erythromycin MoA

50s ribosome and protein synthesis inhibitor

14

Clindamycin MoA

50s ribosome and protein synthesis inhibitor

15

Synercid MoA

50s ribosome and protein synthesis inhibitor

16

Metronidzole MoA

Free radicals break DNA

17

Sulfa MoA

PABA analogue, inhibits purine synthesis

18

Trimethoprim MoA

DHFR inhibitor, inhibits purine synthesis

19

Most common method of abx resistance

Transfer of plasmids

20

PCN resistance

beta-lactamase plasmids

21

MRSA resistance

cell wall binding protein mutation PBP2a

22

Gentamicin resistance

Modifying enzymes cause decreased active transport of gentamicin into bacteria

23

PCN spectrum

Strep, syphilis, N meningitis, C perfringens, GAS, anthrax
Gap: staph and enterococcus

24

Oxacillin and nafcillin spectrum

Staph only: "anti-staph penicillins"

25

Ampicillin and amoxicillin spectrum

strep, syphilis, N meningitides, C perfringens, GAS, anthrax, +enterococcus
Gap: staph

26

Unasyn (amp/sulbactam) and Augmentin (amox/clav) spectrum

GPCs (staph and strep), GNRs, +/- anaerobes, enterococcus
Gap: PAS pseudomonas, acinetobacter, serratia

27

Ticarcillin and piperacillin spectrum

GNRs (pseudomonas, enterics, acinetobacter, serratia)
Side effect: inhibits platelets, high salt load

28

Timentin (ticarcillin/clav) and Zosyn (pip/sulbactam) spectrum

Broad spectrum: GPCs (staph and strep), GNRs, anaerobes, enterococci, PAS pseudomonas, acinetobacter, serratioa
Side effect: inhibits platelets, high salt load

29

Cefazolin, cephalexin (1st gen cephalo) spectrum

GPCs (staph and strep)
Gap: no cephalo for an enterococcus; no CNS
Cefazolin longest t1/2 so good for ppx

30

Cefoxitin, cefotetan, cefuroxime (2nd gen cephalo) spectrum

GPCs, GNRs, +/- anaerobe, los some staph
Gap: enterococcus and CNS
Cefotetan longest t1/2 so good for ppx