Fall 2014: Week 10: Sarcoidosis Flashcards Preview

Fall 2014 Neuro Ophthalmic Disease > Fall 2014: Week 10: Sarcoidosis > Flashcards

Flashcards in Fall 2014: Week 10: Sarcoidosis Deck (10)
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1
Q

What is Sarcoidosis?

A
  1. Multisystem granulomatous disorder of unknown etiology
2
Q

Epidemiology

  1. Amt per 100,000 population?
  2. More common in what race?
  3. Males or females?
  4. Onset?
  5. Acute or chronic Dz?
  6. Affects what the most?
A
  1. 10-20
  2. AA
  3. Females
  4. 20-50 yrs old
  5. either
  6. Lungs, then Lymph Nodes, then Eyes
3
Q

Ocular Involvement

  1. Type of Uveitis?
  2. Infiltrates found where?
  3. Retinal involvement?
  4. ON Involvement?
  5. What else?
A
  1. Granulomatous
  2. Choroid (granuloma)..
  3. Yes. Retinal Periphlebitis
  4. Yes
  5. DRY EYE
4
Q

Pulmonary Involvement

  1. Most common systemic Manifestation
    a. Classified into how many stages?

b. U/L or B/L?
2. Symptoms?

A
  1. a. 4 stages
    b. B/L Hilar Lymphadenopathy
  2. Cough, Shortness of breath, Wheezing, Chest pain
5
Q

Dermatologic Lesions

  1. What 3?
A
  1. Erythema Nodosum
  2. Lupus Pernio
  3. Papules
6
Q

Bones, Joints

  1. What can happen?
A

Migratory Polyarthritis

Painful red inflamed joints

Bone Cysts, Lattice-Like Lesions

Painful Swelling

7
Q

Neurosarcoidosis

  1. Complications in what % of Pts w/Sarcoidosis?
  2. Most COMMON CN PALSY?
  3. Space occupying granulomatous lesion in CNS
    a. INCREASED ICP
    b. Post-Chiasmal
    c. At Chiasm
A
  1. ~5%

Any portion of Central or PNS can be affected

  • Can get U/L or B/L Disc Swelling and Disc Pallor
    2. FACIAL NERVE PALSY
    3. a. Papillema, HAs
    b. Homonymous Hemianopsia
    c. Bitemporal for junctional VF Defect
  • Others: Peripheral neuropathy; Meningitis; Neuroendocrine Dysfunction; Hydrocephalus
8
Q

Diagnostic Testing

  1. Big thing to do?

2.

A
  1. Chest X-ray or CT
    * Tissue Bx (evidence of non-caseating granulomas)

Imaging: Gallium Scans

ACE *increased in 75%!!! or SERUM LYSOZYME

9
Q

Tx?

A

Corticosteroids

Immunosuppressants

Observation

Prognosis: VARIES
a. Can resolve over 1-2 years. Relapsing remitting course
Progressive Dz

10
Q

Review

  1. Cause?
  2. Multisystem: Most Common?
  3. Consider in what eye issue?
  4. Watch for what?
  5. Tx?
A
  1. Idiopathic Granulomatous Dz
  2. Lungs
  3. Granulomatous Uveitis
  4. Neurological signs and symptoms
  5. Corticosteroids
    * Diagnostic Testing