Exam 3 Flashcards Preview

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Flashcards in Exam 3 Deck (23)
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1
Q

Something is wrong with the gland (target organ)

A

primary pituitary disease

2
Q

something wrong with hypothalamus (Rare)

A

tertiary pituitary disease

3
Q

Something wrong in pituitary gland

A

secondary pituitary disease

4
Q

CRF→ corticotrophs release

A

ACTH

5
Q

TRF→ thyrotrophs release

A

TSH

6
Q

FSH/LH-RF→ gonadrotrophs release

A

FSH/LH

7
Q

GHRF→ somatotrophs release

A

GH

8
Q

PIF (dopamine)→ lactotrophs inhibited from releasing

A

PL

9
Q

______ is the most common anterior pituitary tumor

A

Adenoma

*prevalence of 16%

10
Q

histology:

overgrowth of 1 cell type

A

adenoma

*normal has a mixture of cell types

11
Q
Most common (30%)
Produces galactorrhoea and menstrual disturbances
A

Prolactinoma (chromophobe)

12
Q

produces gigantism in children and acromegaly in adults (15%)

A

GH-secreting (esinophil)

13
Q

Producings Cushings disease

A

ACTH-secreting (basophil)

14
Q

No hormone production (27%)

A

null cell

15
Q

how does pituitary adenomas produce clincal disease

A
  1. excess hormone production

2. pressure/mass effect

16
Q

sx of elevated intracranial pressure due to adenomas

A

Headache

nausea/vomitting

17
Q

vision defects due to pressure/mass effect from adenomas

A
  • can result in bitemporal hemianopsia

* pituitary is close to the optic chiasm

18
Q

anterior pituitary release what hormones

A
ACTH
GH
TSH
FSH, LH
Prolactin
MSH
19
Q

posterior pituitary release what hormones

A

ADH aka vasopressin

Oxytocin

20
Q

when does GH spike or get released

A

from deep sleep

*typically undetectable most of the day

21
Q

GH raises ___

A

blood glucose levels

22
Q
  • Binds surface receptors on bone and fat
  • Indirect action through IGF-I (somatomedin C)
  • Leads to increased protein synthesis
  • Accelerates breakdown of fat
A

GH

23
Q

inhibited by undernutrition and hyperglycemia

A

GH