Exam 2 Cancer Meds Flashcards Preview

Q4 Pharm psych > Exam 2 Cancer Meds > Flashcards

Flashcards in Exam 2 Cancer Meds Deck (9)
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1
Q

Antineoplastic agents work how?

This causes toxicity to healthy cells U located where? (4)

A

Suppress rapidly proliferating cells

Bone marrow
GI
Hair follicles
Lymph organs

2
Q

Chemo most damaging to healthy cells when?

A

During actively dividing states

3
Q

Cell Cycle-Specific Agents target what cells?

Given how?

Most effective on what kinds of CA?

A

Cells that are in the particular state the drug is meant to target

Continuously to catch cells as they move thru proliferative cycles

Hematologic
Tumors w/ large portions of cells in proliferation

4
Q

Cell Cycle-Nonspecific Agents work on what cells?

Given how?

Most effective on what kinds of Ca?

A

All cells regardless of cycle

One large dose

Low-growth, solid tumors

5
Q

Chemo more successful in tumors that are? (3)

A

1) Rapidly growing
2) Have high growth fraction (high % of cells are actively dividing)
3) Small (have more cells in growth phase)

6
Q

Large tumors harder for chemo to treat because? (4)

A

1) Penetration is difficult
2) Mets more likely
3) Resistance more likely
4) Just more cells to kill

7
Q

P-glycoprotein is?

A

Glycopro in high concentration in resistant cell membrane,

Works as efflux pump against drug

8
Q

General toxicity of Chemo agents? (6)

A

1) Bone Marrow: ↓ platelets/WBC = hemorr/infection
2) GI: N/V/D, dysphagia
3) Hair: damages follicle
4) Renal: tumor destruction ↑ nucleic acids -> ↑ uric acid -> nephrotox
5) Reproduction: tetratogenic, infertility
6) Vesicant: injection site rxn

9
Q

ABX work to tx CA how?

A

Bind DNA -> block syth or replication, cut the strand