Exam 2 Autoimmunity/ Immunodeficiency Flashcards Preview

RUSVM Immunology 2016 > Exam 2 Autoimmunity/ Immunodeficiency > Flashcards

Flashcards in Exam 2 Autoimmunity/ Immunodeficiency Deck (18)
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1
Q

What are factors related with autoimmunity?

A

sex, age and viruses

2
Q

What are the two types of autoimmunity?

A

inability to regulate the immune response or abnormal immune response to normal antigen

3
Q

autoimmunity

A

immune systems self reactive response

4
Q

Autoimmunity can be causes by

A

hidden antigens (testis, RBC, etc), Molecular changes in Ab or infections (retrovirus)

5
Q

Cross reaction with self antigens causes

A

the production of self antigen when exposed to foreign antigen

6
Q

What are predisposing factors for hypersensitivity reactions?

A

genetics, breed and intestinal microflora

7
Q

Myastenia gravis is an autoimmune disease in which,

A

myastenia gravis blocks receptors for acetylcholine, causing muscle paralysis

8
Q

What is the difference between autoimmunity and immune suppression?

A

Autoimmunity is the immune system reacting to itself, where immune suppression is decreasing the immune response

9
Q

What are levels of primary immunodeficiencies?

A

Failure of:

  1. pluripotent stem cells
  2. committed stem cells
  3. T cell development
  4. B cell development
  5. B cell maturation to plasma cells
  6. production of selected Igs classes
  7. production of functional phagocytic cells
  8. production of complement molecules
10
Q

Primary immune deficiencies are primarily caused by

A

gene defects

11
Q

Secondary immune deficiencies are primarily caused by

A

chronic diseases

12
Q

Primary immunodeficiences can be treated with:

A

bone marrow transplantation, transplant of heterologous stem cells, or gene therapy

13
Q

Thymic aplasia is what kind of immune deficiency?

A

primary immunodeficiences

14
Q

Thymic aplasia is caused by what?

A

lack of a thymus or thymus doesn’t develope, causing no humoral immune response

15
Q

autoantigen

A

self-antigens; that are components of the host’s own body and recognized by the immune system

16
Q

alloantigen

A

antigens carried by foreign cells or tissue from a genetically unrelated member of the same species

17
Q

xenoantigen

A

antigens that are present in graft tissue derived from different species

18
Q

Privileged organs/tissues include

A

anterior chamber of the eye, cornea, thymus, testes, brain