Evaluation of Erythrocytes: Anemia and Regeneration Flashcards Preview

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Compare lab findings in chronic iron deficiency anemia vs. anemia of inflammatory disease. 


Where does non-regenerative immune-mediated anemia usually occur?

in bone marrow - destruction of RBC precursors, very hard to control


What can cause selective erythroid aplasia?

immune mediated - dogs and cats

FeLV subgroup C - cats

chloramphenicol - cats

rhEPO use - dogs, cats, horses

congenital - dogs

parvovirus vaccine in dogs?


Name two groups that suffer from inherited dyserythropoiesis.

polled hereford calves

English Spaniel Springer dogs


How can you definitively tell an anemia is nonregenerative?

hypoplastic or aplastic bone marrow

proliferation or infiltration of abnormal cells into the bone marrow


Name some causes of aplastic anemia. 


Which infectious agents can cause hypoplastic marrow?

chronic Ehrlichia canis infections in dogs

FeLV and parvovirus coinfection in cats

parvovirus infection in young dogs


What are myelophthsises?

  • a normocytic-normochromic anemia that occurs when normal marrow space is infiltrated and replaced by nonhematopoietic or abnormal cells.
  • Causes include tumors, granulomatous disorders, and lipid storage diseases.
  • Characteristic changes in peripheral blood include anisocytosis, poikilocytosis, and excessive numbers of RBC and WBC precursors. 


Name some examples of myelophtisis. 

myelogenous leukemias

lymphoid leukemias

myelodysplastic syndromes

multiple myeloma

myelofibrosis and/or osteosclerosis

metastatic neoplasia (primarily lymphomas and mast cell tumors)


Relative erythrocytosis occurs due to?

  • splenic contraction
    • excitement
    • exercise 
    • pain
  • dehydration
    • water loss
    • water deprivation
    • shock with fluid shift into tissues


What is absolute erythrocytosis?

primary - normal or low EPO but lots of RBCs, can be due to a condition called polycythemia vera, happens in cattle?

secondary - high EPO, hypoxemia (ie. high altitude, heart dz, chronic lung dz, methemoglobinemia) or innapropriate EPO production (renal tumors, renal cysts, hydronephrosis, non-renal EPO secreting tumors)