Erythropoiesis Flashcards Preview

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Flashcards in Erythropoiesis Deck (16)
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1
Q

What is Diapedesis?

A

The passage of blood cells through the intact walls of the capillaries.

2
Q

Does a reticulocyte have a nucleus?

A

No, it doesn’t have a nucleus. It does have some basophilic substance with remnants of the Golgi apparatus, mitochondria, etc.

3
Q

What comes after Proerythroblast?

A

Basophilic Erythroblast

4
Q

What comes before Proerythroblast?

A

CFU-E stem cells which are committed stem cells

5
Q

What causes the formation of growth inducers and differentiation inducers?

A

Hypoxia in the case of RBCs

Any infection in the case of WBCs

6
Q

What does Tissue hypoxia lead to the production of?

A

Hypoxia-Inducible Factor-1 (HIF-1)

7
Q

Function of HIF-1

A

Activates the erythropoietin gene.

8
Q

Functions of Erythropoietin

A

Stimulates the production of proerythroblasts.

Speed up the process of erythropoiesis.

9
Q

Extramedullary hematopoiesis

A

Hematopoiesis occurring outside of the medulla of the bone (bone marrow). It occurs in fetal life.

10
Q

Vitamin B12 and folic acid are necessary for?

A

DNA synthesis

11
Q

The other name of folic acid is?

A

Pteroylglutamic acid

12
Q

Where is iron stored in our bodies?

A

Reticuloendothelial cells in the liver parenchyma in the form of ferritin.

13
Q

Fe2+ combines with apoferritin to form?

A

Ferritin

14
Q

What is Transferrin?

A

Fe2+ combined with the protein apotransferrin is called Transferrin.

15
Q

Journey of Transferrin

A

Transferrin goes to the bone marrow and it binds to the cell membrane of the erythroblast and taken in by endocytosis.

16
Q

Hemosiderin

A

When a group of ferritin molecules with low iron accumulates, it is called hemosiderin.