Endocrinology Basics I and II Flashcards Preview

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Flashcards in Endocrinology Basics I and II Deck (49)
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1

What are classes of the amine hormones?

Catecholamines
Indoleamines
Thyroid Hormones

2

What are the monoamines?

Catecholamines
Indoleamines

3

What is the half life of monoamines like?

VERY short (2-3 minutes)

4

What is the half life of peptide hormones like?

Medium length (4-170 minutes)

5

What is the half life of steroid like?

Long (minutes to hours)

6

What are examples of catecholamines?

Dopamine
Norepinephrine
Epinephrine

7

What is the precursor for catecholamines?

Tyrosine

8

What is the enzyme for the rate limiting step for the formation of catecholamines?

Tyrosine Hydroxylase

9

What is Tyrosine Hydroxylase activated by?

Sympathetic Activity

10

What is Tyrosine Hydroxylase activated by?

Sympathetic Activity

11

What are the main 2 organs that dopamine is made in?

Brain and Adrenal Gland

12

What is the NT function of dopamine?

Activates reward pathways and is involved in attention and mood

13

What is the hormone function of dopamine?

Inhibits prolactin release from the anterior pituitary

14

What is the hormone function of dopamine?

Inhibits prolactin release from the anterior pituitary

15

Where do dopaminergic neurons arise from?

Arcuate nucleus

16

What converts dopamine into norepinephrine?

Dopamine Beta-hydroxylase

17

Where is norepinephrine converted into epinephrine?

Adrenal Glands

18

What is the enzyme for the rate limiting step for the formation of catecholamines?

Tyrosine Hydroxylase

19

Where is norepinephrine converted into epinephrine?

Adrenal Glands

20

What is the precursor for indoleamines?

Tryptophan

21

What is the enzyme for the rate limiting step for the formation of indoleamines?

Tryptophan Hydroxylase

22

What are examples of indoleamines?

Serotonin
Melatonin

23

What is the function of serotonin in the brain?

It is the "happiness" hormone

24

What is the function of serotonin in the body?

Serves as a vasoconstrictor and stimulates smooth muscle contraction

25

What produces most of the serotonin in the body?

Enterochromaffin cells in the gut

26

What is the function of drugs that act as selective serotonin reuptake inhibitors?

SSRIs work to increase the concentration of serotonin at the synaptic cleft and is used to treat depression.

Causes negative feedback on serotonin synthesis.

27

What is the main enzyme in monoamine metabolism?

Monoamine Oxidase

28

What is measured in urine to determine the catecholamine levels?

VMA

29

Where is melatonin made?

Pineal Gland

30

How is melatonin made?

It is converted from tryptophan into serotonin into melatonin

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