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Flashcards in Endocrine Disruptors Deck (17)
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1

What are the hormones secreted by the kidney?

Renin
Erythropoietin
Vitamin D

2

What are the hormones of the heart?

ANP
BNP

3

What are the hormones of the liver?

IGF-I

4

What are the hormones of the GI tract?

Serotonin
Ghrelin

5

What are some of the non-classical endocrine glands?

Brain
Kidney
Heart
Liver
GI

6

Where is renin made?

In the juxtoglomerluar cells of afferent arterioles in the kidney

7

What is the function of renin?

Regulation of the arteriolar diameter

8

What is the molecular action of renin?

Cleaves angiotensinogen to angiotensin I -> precursor for angiotensin II

9

What is the function of erythropoietin?

Stimulates proerythroblasts and differentiation of red blood cells (increases cell number)

10

What are some regulators of EPO?

Anemia
Hypoxia
Thyroid Hormone
NE
Androgens

11

What is the major side effect of blood doping?

Hypertension

12

What is the function of ANP/BNP?

They will decrease the overall blood volume by increasing the rate of water and Na excretion. It also relaxes the blood vessels

13

What is the effect of ANP/BNP on the hematocrit?

It will increase it due to the decrease in blood volume

14

What can normal levels of BNP rule out?

CHF

15

What are endocrine disruptors?

Any chemicals that may interfere with the body’s endocrine system and produce adverse developmental, reproductive, neurological, and immune effects in both humans and wildlife

16

How do PCBs act as endocrine disruptors?

PCBs compete with thyroid hormone binding to its transport protein in the blood (TTR; TBG) which will increase the breakdown of thyroid hormone in the blood and result in excessive thyroid hormone production and a goiter.

17

How does Diethylstilbestrol (DES) act as an endocrine disruptor?

Non-steroidal synthetic estrogen used in cattle feed that can mimic the effects of estrogen.

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