Flashcards in Endocrine Disruptors Deck (17)
What are the hormones secreted by the kidney?
What are the hormones of the heart?
What are the hormones of the liver?
What are the hormones of the GI tract?
What are some of the non-classical endocrine glands?
Where is renin made?
In the juxtoglomerluar cells of afferent arterioles in the kidney
What is the function of renin?
Regulation of the arteriolar diameter
What is the molecular action of renin?
Cleaves angiotensinogen to angiotensin I -> precursor for angiotensin II
What is the function of erythropoietin?
Stimulates proerythroblasts and differentiation of red blood cells (increases cell number)
What are some regulators of EPO?
What is the major side effect of blood doping?
What is the function of ANP/BNP?
They will decrease the overall blood volume by increasing the rate of water and Na excretion. It also relaxes the blood vessels
What is the effect of ANP/BNP on the hematocrit?
It will increase it due to the decrease in blood volume
What can normal levels of BNP rule out?
What are endocrine disruptors?
Any chemicals that may interfere with the body’s endocrine system and produce adverse developmental, reproductive, neurological, and immune effects in both humans and wildlife
How do PCBs act as endocrine disruptors?
PCBs compete with thyroid hormone binding to its transport protein in the blood (TTR; TBG) which will increase the breakdown of thyroid hormone in the blood and result in excessive thyroid hormone production and a goiter.