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Flashcards in Endocrine Deck (254)
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91

What two tumors can secrete ACTH?

small cell lung

bronchial carcinoid

92

What does lack of inhibition by dexamethasone mean?

ectopic ACTH production

93

What is another name for Primary Hyperaldosteronism?

Conn Syndrome

94

Would Conn Syndrome have low or high plasma renin?

low

95

What drug would be used in Conn Syndrome?

Spironolactone

96

What causes Secondary Hyperaldosteronism?

Renal perception of low intravascular volumes

97

Would Secondary Hyperaldosteronism present with high or low plasma renin?

high

98

What is the treatment for Secondary Hyperaldosteronism?

spironolactone

99

What is secondary adrenal insufficiency?

decreased response to ACTH

100

What cells does a neuroblastoma originate from?

neural crest

101

Which does not cross the midline, Wilms or Neuroblastoma?

Wilms = not cross midline

Neuroblastoma = can cross

102

What is an easy mechanism to diagnose Neuroblastoma?

homovanillic acid in urine

103

What gene is neuroblastoma associated with?

N-myc

104

What is the tumor marker for Bombesin?

Neuroblastoma

105

What is homovanillic acid a breakdown product of?

Dopamine

106

What cells does a pheochromocytoma originate from?

neural crest

107

Which three diseases can result in a pheochromocytoma?

VHL

MEN2A

MEN2B

108

What is found in the urine during a pheochromocytoma?

VMA

109

What is VMA a breakdown product of?

epinephrine and norepinephrine

110

Which is given first during a pheochromocytoma, α-blockers or β-blockers?

α-blockers

111

Why does hypothyroidism present with hypercholesterolemia?

thyroid hormone upregulates LDL receptor

112

Why does hyperthyroidism present with hypocholesterolemia?

increase LDL receptor expression

113

What are the two autoantibodies present during Hashimotos?

anti-thyroglobulin

anti-thyroid peroxidase

114

What is the HLA haplotype most often found during Hashimotos Thyroiditis?

HLA-DR5

115

Is Hashimotos a tender or nontender thyroid?

non-tender

116

What structure is present during Hashimotos Thyroiditis?

germinal centers

117

What type of inflammation is present during de Quervain thyroiditis?

granulomatous

118

Is de Quervain painful or painless?

painful

119

What is the course of thyroid hormone release during DeQuervains?

transient hyper

followed by hypo

120

Does Riedel Thyroiditis present with hypothyroidism or hyperthyroidism?

hypothyroidism