Electron Transport Chain Flashcards Preview

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Flashcards in Electron Transport Chain Deck (15)
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1
Q

Name the components of the ETC

A
  1. FMN
  2. Fe-S centers
  3. Coenzyme Q
  4. Cytochromes b, c1, c, and aa3
2
Q

Cyanide poisonong binds Fe3+ in cytochorme ____ resulting to ___

A

Cyt AA3, blocks O2 as final electron acceptor

3
Q

NADH passes electrons via ____ while FMN passes the electrons to a series of ____ complexes

A

NADH : complex I )NADH dehydrogenase complex) to GMN

FMN to Fe-S complexes to Coenzyme Q

4
Q

Coenzyme q passes the electrons through Fe-S centers to cytochromes ____ and ___ which transfers these electrons to cytochrome ____

A

CoQ to b and c1 then to cyt C

5
Q

Electrons from FADH2 enter the ETC at ____ which contains ____ enzyme.

A

complex II, succinate dehydrogenase

6
Q

Cytochrome oxidase ___ catalyzes the transfer of electrons from cyt C to cyt aa3 complex

A

IV

7
Q

___ mineral that is present cytochromes a and a3

A

copper

8
Q

(Inhibitor of ETC) ____ complexes with complex I causing NADH accumulation

A

Rotenone (rotenONE)

Amytal

9
Q

(inhibitor of ETC) ___ block the passage of electrons through the cyt b-c1 complex III

A

Antimycin (antimicin = 3 i = iii = complex 3)

10
Q

(inhibitor of ETC) _____ and ____ block complex IV

A

Cyanide and CO

11
Q

(inhibitor of AT synthesis) ____ inhibits ANT resulting to lack of ADP in the mitochondrial matrix

A

Atracycloside

12
Q

____ is an uncoupler since it allows protons from the cytosol to reenter the matrix without going through the ATP synthase complex

A

dinitrophenol

13
Q

(deletion of contiguous segment of tRNA and OXPHOS) ___ syndrome ophthalmoplegia, atypical retinitis pigmentosa, mitochondrial myopathy, cardiac conduction defect, cerebellar syndrome, elevated CSF

A

Kearns-Sayre syndrome

14
Q

(mtDNA missense mutation) ___ disease optic atrophy, ophthalmoplegia, nystagmus, respiratory abnormalities, ataxia, hypotonia, spasticity, develpmental delay, regression

A

leigh disease

15
Q

Glutathione is composed of ___ amino acids.

A

gamma-glutamyl-cysteine-glycine