Dyspepsia + Peptic Ulcer Disease Flashcards

1
Q

What are the 2 groups of causes of dyspepsia? Which is most common?

A
Organic causes
Functional dyspepsia (most common)
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2
Q

Give examples of organic causes of dyspepsia

A

Peptic ulcer disease
Drugs (NSAIDs)
Gastric cancer

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3
Q

What is meant by functional dyspepsia?

A

Dyspepsia symptoms with no evidence of structural disease, i.e. not due to ulcers or H. pylori
Usually assoc. with functional gut disorders

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4
Q

Is dyspepsia the same as GORD?

A

Nope

Dyspepsia is a range of symptoms with multiple causes; GORD is due to reflux of acid from the stomach

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5
Q

Outline the Rome III criteria for functional dyspepsia

A

Feeling of fullness or epigastric pain/burning
AND no evidence of structural disease
For past 3 months, with symptom onset 6 months before diagnosis

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6
Q

What is the commonest organic cause of dyspepsia?

A

Peptic ulcer disease

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7
Q

When does pain related to peptic ulcer disease often come on?

A

At night after eating

Duodenal ulcers aggravated by stomach emptying

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8
Q

What are the two most common causes of peptic ulcer disease?

A

H. pylori

Drugs (NSAIDs)

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9
Q

Where are peptic ulcers more common - the oesophagus, stomach or duodenum?

A

Duodenum

Then stomach; don’t really occur in oesophagus

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10
Q

What tests are done to diagnose H. pylori infection?

A

Stool antigen test
Urease breath test
Serology (IgA antibodies)

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11
Q

Which drugs are used to treat peptic ulcer disease?

A

Antacids (Gaviscon)
H2 antagonists (ranitidine)
PPI (omeprazole)

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12
Q

Outline triple therapy for H. pylori eradication

A

Omeprazole + amoxicillin + clarithromycin

Omeprazole + metronidazole + clarithromycin

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13
Q

If a patient is still symptomatic after H. pylori triple therapy, a retest to detect the organism is done. How long must a PPI be stopped before retest is done?

A

2 weeks

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