Drugs for Rheumatoid Arthritis Flashcards Preview

18 Musculoskeletal System > Drugs for Rheumatoid Arthritis > Flashcards

Flashcards in Drugs for Rheumatoid Arthritis Deck (15)
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1

anakinra

IL-1 receptor blocker

2

how are adalimumab and etanercept different in mech?

-etanercept binds only soluble TNF-alpha

-adalimumab binds both soluble and transmembrane

2

methotrexate

-DHFR inhibitor, inhibits folate dependent steps in purine synthesis to inhibit DNA synthesis

3

etanercept

-mech

-therapeutic use

-adverse effects (3)

'intercept TNF alpha'

-binds to soluble TNF-alpha

-used for RA

 

-side effects:

1. injection site reactions

2. increased risk of infections

3. lymphoma in children

4

tofacitinib

-mech

-use

-side effects --2

 

-JAK inhibitor

-used in active RA pts who had inadequate repsonse from methotrexate

 

adverse effects:

1. increase infection risk

2. increase in cholesterol

5

Infliximab

TNF alpha inhibitor

6

tocilizumab

-mech

-therapeutic use

-side effects (2)

-IL-6 receptor blocker. (both soluble and transmembrane)

-used for adult RA with poor response to TNF anatgonists

side effects:

1. injection site reactions

2. increase infection risk

 

7

adalimumab

-mech

-therapeutic use

-adverse effects--3

-IgG that binds TNF-alpha (both soluble and transmembrane)

-active RA, juvenile idiopathic arthritis

-side effects:

1. injection site reactions

2. increased risk of infections

3. lymphoma in children

8

azathioprine

-prodrug to 6-MP

-purine antimetabolite to inhibit DNA synthesis

9

DMARDs

disease-modifying anti-rheumatic drugs

-protein drugs that target cytokines and cell surface molecules

10

abatacept

-inhibits T-cell activation by blocking the CD28/B7 costimulation of APCs on T cells.

-abatecept (which has CTLA-4) competes with B7 to bind CD28. This induces anergy.

11

hydroxychloroquine

-mech not understood

-useful as oral tx for early RA

-long term toxicity: irreversible retinal damage

12

leflunomide

-inhibits dihydroorotate DH (DHODH), an enzyme that produces UMP

14

what drugs require the pt to be screened for latent TB infection and monitored while taking it? why?

-etanercept, adalimumab, infliximab

-as TNF-alpha inhibitor, the inflammatory response is reduced. This could allow a latent TB infection to relapse

15

rituximab

-Ab against CD20 antigen of B-cells, inducing complement and destroying them