Rofecoxib
Vioxx
COX2 inhibitor
Decrease PGI2 vs TXA2-MI
indomethacin
NSAID
ibuprofin
NSAID
diclofenac
NSAID
naproxen
NSAID
Celecoxib
celebrex
Cox 2 inhibitor Decrease PGI2 (cox1) vs TXA2 (cox2)-MI
Leukotriene inhibtors
Decrease leukotriene by blocking lipoxygenase
Block receptor cite for leukotriene
Effective in trx aspirin asthma
Less effective than corticosteroid but tolerated better
Acetominophin
erase PGE2 syn in hypothalmus
NAPQI
NAC
CYP450
hydrocortisone
reduce PLP2A
-decrase macrophage and mast cell effects
anti-inflammatory/immosupress
prednisolone
reduce PLP2A
-decrase macrophage and mast cell effects
anti-inflammatory/immosupress
dexamethasone
reduce PLP2A
-decrase macrophage and mast cell effects
anti-inflammatory/immosupress
bethamasone
reduce PLP2A
-decrase macrophage and mast cell effects
anti-inflammatory/immosupress
-cept
receptor-looks like Ab
-mab
ximab
umab
monoclonal ab
xi-chimeric
umab-full human
Rhogam
anti RhD ab (that have RhD Ag)
- kill fetal RBC
- Ab feedback (decrease prod)
- interrup cytokines
certizine
zyrtec
2nd gen
loratidine
claratin
2nd gen
fexofenidine
allegra
2nd gen
levocetrizine
xyzal
3rd gen
desloratidine
clarinex
3rd gen
-amine
-zine
+1 other
1st generation H1 inhibitors
cyproheptadine
-dines
bad fx?
except cyproheptadine
piperidine (class)
anti androgen/estradiol
neurologic if kidney/liver fucked
p450-slows down other drugs
Cromolyn
mast cell stabilizer
Nedocromil
mast cell stabilizer
1st gen h1 inhibitor problems
CNS too
anticholinergic-dry/vision
alcohol drug interaction-sleepy
Cyclosporine
stop NFKA act by no Ca-calmodulin activation
no IL2
CYP450
Tacrolimide
stop NFKA act by no Ca-calmodulin activation
no IL2
CYP450
more potent-FK506
Sirolimus
Rampamaycin
inhibit mTOR-decrase cell growth
Increase TAg/cholesterol
CYP450
Everolines
shorter 1/2 life than sirolimus
inhibit mTOR-decrase cell growth
Increase TAg/cholesterol
CYP450
Azothiprine
cytotoxic
act by glutathione,deg by xanthin ox
-mess up DNA replication
Transplant, RA
Mycophenol motefil
inhibit IMPDH-needed for de novo purine sun
prevent rejection
give with caniurninean
Anti lymphocyte/thymocyte AB
best for BMT
immunosuppress
Duclizimab
Antibody for IL2
immunosuppress
Muromonab CD3
Destruction of T cells by binding to CD3-antibody
immunosuppress
glucocorts
inhibit cytokine exp, T cell proliferation, T cell def immunity
Inhabit PLP2
Leflunomide
DMARD
- first line trx
- prevent proliferation of lymphocytes and decrease inflammation
RA
methotrexate
DMARD
- first line trx
- prevent proliferation of lymphocytes and decrease inflammation
RA
Etanercept
Decoy receptor for TNFa
submit weekly injection
trx with MTX
RA
Infliximab
chimeric man to TNFa
IV infusion
Critical part-Fab-mouse
Hepatotoxicity
RA/Chrons
adalimumab
human man to TNFa
subcutaneous injection
decrease MTX clearance
RA
Secukinumab
anti IL17 Ab
RA
Anakinra
IL1 R antagonist
cant be used with TNF Ab
no longer used
RA
Abatacept
CTLA4 Ig, binds to B7 on DC
-block T cell activation
IV
can’t use with Ab
RA
certolizumab
Binds TNFa
- subcutanous injection
- RA/Chrons
BAFF-B lymphocyte stim (Blys)
key determinant of B cell survival
excess-pro-inflamm/tissue destruct @
Belimumab
Benlysta
Man to BAFF/Blys
Secukinumab
IL 17 antagonist
injuectible
psoriasis/asthma
Omalizmab
IgE specific Ab
Induction therapy (3 drugs)
antithymocyte globulin-depleting
daclizmumab-anti IL2 R-immune mod
Muromonab-CD3-msMAB
both