DRUGS 4 REAL Flashcards Preview

Immuno > DRUGS 4 REAL > Flashcards

Flashcards in DRUGS 4 REAL Deck (49)
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1
Q

Rofecoxib

A

Vioxx

COX2 inhibitor
Decrease PGI2 vs TXA2-MI

2
Q

indomethacin

A

NSAID

3
Q

ibuprofin

A

NSAID

4
Q

diclofenac

A

NSAID

5
Q

naproxen

A

NSAID

6
Q

Celecoxib

A

celebrex

Cox 2 inhibitor
Decrease PGI2 (cox1) vs TXA2 (cox2)-MI
7
Q

Leukotriene inhibtors

A

Decrease leukotriene by blocking lipoxygenase

Block receptor cite for leukotriene

Effective in trx aspirin asthma

Less effective than corticosteroid but tolerated better

8
Q

Acetominophin

A

erase PGE2 syn in hypothalmus

NAPQI

NAC

CYP450

9
Q

hydrocortisone

A

reduce PLP2A
-decrase macrophage and mast cell effects

anti-inflammatory/immosupress

10
Q

prednisolone

A

reduce PLP2A
-decrase macrophage and mast cell effects

anti-inflammatory/immosupress

11
Q

dexamethasone

A

reduce PLP2A
-decrase macrophage and mast cell effects

anti-inflammatory/immosupress

12
Q

bethamasone

A

reduce PLP2A
-decrase macrophage and mast cell effects

anti-inflammatory/immosupress

13
Q

-cept

A

receptor-looks like Ab

14
Q

-mab

ximab
umab

A

monoclonal ab

xi-chimeric
umab-full human

15
Q

Rhogam

A

anti RhD ab (that have RhD Ag)

  • kill fetal RBC
  • Ab feedback (decrease prod)
  • interrup cytokines
16
Q

certizine

A

zyrtec

2nd gen

17
Q

loratidine

A

claratin

2nd gen

18
Q

fexofenidine

A

allegra

2nd gen

19
Q

levocetrizine

A

xyzal

3rd gen

20
Q

desloratidine

A

clarinex

3rd gen

21
Q

-amine
-zine
+1 other

A

1st generation H1 inhibitors

cyproheptadine

22
Q

-dines

bad fx?

A

except cyproheptadine
piperidine (class)

anti androgen/estradiol
neurologic if kidney/liver fucked
p450-slows down other drugs

23
Q

Cromolyn

A

mast cell stabilizer

24
Q

Nedocromil

A

mast cell stabilizer

25
Q

1st gen h1 inhibitor problems

A

CNS too
anticholinergic-dry/vision
alcohol drug interaction-sleepy

26
Q

Cyclosporine

A

stop NFKA act by no Ca-calmodulin activation

no IL2

CYP450

27
Q

Tacrolimide

A

stop NFKA act by no Ca-calmodulin activation

no IL2

CYP450

more potent-FK506

28
Q

Sirolimus

A

Rampamaycin

inhibit mTOR-decrase cell growth

Increase TAg/cholesterol

CYP450

29
Q

Everolines

A

shorter 1/2 life than sirolimus

inhibit mTOR-decrase cell growth

Increase TAg/cholesterol

CYP450

30
Q

Azothiprine

A

cytotoxic

act by glutathione,deg by xanthin ox
-mess up DNA replication

Transplant, RA

31
Q

Mycophenol motefil

A

inhibit IMPDH-needed for de novo purine sun

prevent rejection

give with caniurninean

32
Q

Anti lymphocyte/thymocyte AB

A

best for BMT

immunosuppress

33
Q

Duclizimab

A

Antibody for IL2

immunosuppress

34
Q

Muromonab CD3

A

Destruction of T cells by binding to CD3-antibody

immunosuppress

35
Q

glucocorts

A

inhibit cytokine exp, T cell proliferation, T cell def immunity

Inhabit PLP2

36
Q

Leflunomide

A

DMARD

  • first line trx
  • prevent proliferation of lymphocytes and decrease inflammation

RA

37
Q

methotrexate

A

DMARD

  • first line trx
  • prevent proliferation of lymphocytes and decrease inflammation

RA

38
Q

Etanercept

A

Decoy receptor for TNFa
submit weekly injection
trx with MTX

RA

39
Q

Infliximab

A

chimeric man to TNFa
IV infusion
Critical part-Fab-mouse
Hepatotoxicity

RA/Chrons

40
Q

adalimumab

A

human man to TNFa
subcutaneous injection
decrease MTX clearance

RA

41
Q

Secukinumab

A

anti IL17 Ab

RA

42
Q

Anakinra

A

IL1 R antagonist
cant be used with TNF Ab
no longer used

RA

43
Q

Abatacept

A

CTLA4 Ig, binds to B7 on DC
-block T cell activation

IV

can’t use with Ab

RA

44
Q

certolizumab

A

Binds TNFa

  • subcutanous injection
  • RA/Chrons
45
Q

BAFF-B lymphocyte stim (Blys)

A

key determinant of B cell survival

excess-pro-inflamm/tissue destruct @

46
Q

Belimumab

A

Benlysta

Man to BAFF/Blys

47
Q

Secukinumab

A

IL 17 antagonist
injuectible

psoriasis/asthma

48
Q

Omalizmab

A

IgE specific Ab

49
Q

Induction therapy (3 drugs)

A

antithymocyte globulin-depleting

daclizmumab-anti IL2 R-immune mod

Muromonab-CD3-msMAB
both