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Flashcards in Drugs Deck (12)
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1
Q

What is MOA of ASA?

A

Binds to plt and prevents thomboxane production, which usually binds plt together

2
Q

What is MOA of plavix?

A

thienopyridine
Irreversibly dinds to PLT receptor P2Y12 (ADP receptor) on plt cell memebrane
This is important site for plt activation and corss linking

3
Q

Name three thienopyridines.

A

prasugrel
ticlopidine
clopidogrel

4
Q

What is MOA of IIbIIIa inhibitors?

A

Inhibit IIbIIIa receptor on plt and prevent plt aggregation and thrombus formation

5
Q

Name three IIbIIIa inhibitors.

A

Abciximab, eptifibatide, tirofiban

6
Q

What is MOA of ACEi?

A

Reduce activity of RAAS

Block conversion of AI to AII

7
Q

What is MOA of beta blocker?

A

Block the endogenous action of catecholamines epi and norepi on adrenergic beta receptors

8
Q

What is MOA of Heparin?

A

binds to enzyme inhibitor ATII causing conformational change that activates it.

9
Q

What factors does ATIII inhibits.

A
thrombin
IXa
Xa
XIa
XIIa
10
Q

What is the does for protamine?

A

1-1.5mg for every 100 IU of heparin

11
Q

What is MOA of protamine?

A

binds to heparin or LMWH and forms ion pair inactivating heparin

12
Q

What is MOA of dipyridamole?

A

Inhibits phosphodiesterase enzyme that normally breaks down camp and cGMP

acts as vasoD when administered rapidly at high dose