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Flashcards in drugs 2 Deck (11)
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1
Q

nucleoside analogs 3

A

acyclovir-guanine derivative, viral DNA pol inhibitor, need TK for monophopshoprylation (no CMV)

cidofovir-2 phosphates added-cytosine derivative-neprhotox

topical-viral DNA polyermase inhibitors-Trifluridie and virdrabine

2
Q

foscarnet

A

blocks viral DNA/RNA pol and HIV RT directly preventing cleavage-neprhotox (Ca and P concentration changes) and penile ulcerations

3
Q

drugs for CMV and Herpes 4

A

acycoivr, cidofovir, topical, and foscanet

4
Q

Influenza drugs 4

and side effects

A

Amantidine/Rimantidine-binds to M2 and blocks unsheathing (viral entry)-only used on HBA

CNS and dose related GI

Zanamivir/Oseltamivir (O is prodrug activated by esterase)-inhibit viral neuramidase activity so can’t escape cell and will agglutinate

Renal and GI tox if renal messe dup

5
Q

IFN for what diseases

A

HBV/HCV

6
Q

HBV treating nucleoside analogs

A

Tenofovir-2 types-nephrotoxic and decrease bone mineral density

Entecavir-guanine nucleoside analog

7
Q

HCV treating nucleoside analogs

A

Ribavirin-GUaisine analog that lowers GTP levels, inhibits mRNA capping, and virus replication
-some get hemolytic anemia

Sofosbuvir-urine chain terminator of NS5B RNA deg RNA polyermase-prodrug

8
Q

HCV RNA pol Inhibitor

A

Dasabuvir

9
Q

HCV Protease inhibitors

A

can’t cleave poly protein

Simiprevir
Paritaprevir
Grazoprevir

10
Q

HVC NS5a inhibitors

A

Inhibits a structural protein so messes with viral RNA prellicatio and packaging

Ledipasvir
Ombitasvir
Daclatasvir
Elbasvir

11
Q

HCV Combos

A

Harvoni-Lepiasvir and sofosbuvir

Vieikra Pak
-Paraitaprevir, ritonavir (part booster), ombitasvir

Dasabuvir-non nucleoside inhibitor of NCV RNA DEP RNA POLY