nucleoside analogs 3
acyclovir-guanine derivative, viral DNA pol inhibitor, need TK for monophopshoprylation (no CMV)
cidofovir-2 phosphates added-cytosine derivative-neprhotox
topical-viral DNA polyermase inhibitors-Trifluridie and virdrabine
foscarnet
blocks viral DNA/RNA pol and HIV RT directly preventing cleavage-neprhotox (Ca and P concentration changes) and penile ulcerations
drugs for CMV and Herpes 4
acycoivr, cidofovir, topical, and foscanet
Influenza drugs 4
and side effects
Amantidine/Rimantidine-binds to M2 and blocks unsheathing (viral entry)-only used on HBA
CNS and dose related GI
Zanamivir/Oseltamivir (O is prodrug activated by esterase)-inhibit viral neuramidase activity so can’t escape cell and will agglutinate
Renal and GI tox if renal messe dup
IFN for what diseases
HBV/HCV
HBV treating nucleoside analogs
Tenofovir-2 types-nephrotoxic and decrease bone mineral density
Entecavir-guanine nucleoside analog
HCV treating nucleoside analogs
Ribavirin-GUaisine analog that lowers GTP levels, inhibits mRNA capping, and virus replication
-some get hemolytic anemia
Sofosbuvir-urine chain terminator of NS5B RNA deg RNA polyermase-prodrug
HCV RNA pol Inhibitor
Dasabuvir
HCV Protease inhibitors
can’t cleave poly protein
Simiprevir
Paritaprevir
Grazoprevir
HVC NS5a inhibitors
Inhibits a structural protein so messes with viral RNA prellicatio and packaging
Ledipasvir
Ombitasvir
Daclatasvir
Elbasvir
HCV Combos
Harvoni-Lepiasvir and sofosbuvir
Vieikra Pak
-Paraitaprevir, ritonavir (part booster), ombitasvir
Dasabuvir-non nucleoside inhibitor of NCV RNA DEP RNA POLY