Flashcards in Drug Therapy With Aminoglycosides and Fluoroquinolones CH 17 E3 Deck (3)
Concentration-dependent bactericidal effect
relation of bactericidal ability of a drug to its concentration; the greater the concentration of the drug, the faster and the more extensive the killing of the bacteria. The goal is to maximize concentration of the drug. Once-daily dosing—single daily aminoglycoside dosing, typically using a dose of 7 mg per kg every 24 hours, or longer in patients with renal impairment.
adverse effects on the structures of the ear, especially the cochlea and auditory nerve