Diuretics Flashcards Preview

Pharmacology > Diuretics > Flashcards

Flashcards in Diuretics Deck (23)
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1
Q

used in

A

animals retaining water in various organs

2
Q

Does interference with Na+ absorption at one site interfere with other renal functions linked to it and lead to inc. Na+ absorption at other sites?

A

yes

3
Q

all diuretics, except spironolactone, act from the _________ side of the tubular cellular membrane

A

luminal!

4
Q

freely filtered at glomerulus, not metabolized, hyperosmolality creates a water shift, impairs passive water reabsorption

A

osmotic diuretics

5
Q

most common osmotic diuretic

A

mannitol

6
Q

cases of cerebral edema and inc. intracranial Pressure (ICP) should use _____, clinical effect seen in minutes (animal becomes more responsive)

A

mannitol

7
Q

contraindicated in cases of CHF

A

mannitol

8
Q

loop diuretics

A

inhibit symporter(Na, K, Cl) on luminal side, -> decrease absorption of Ca2+ Mg2+ also

9
Q

Go to drug for management of Heart failure

A

loop diuretics (furosemide)

10
Q

strongest diuretic

A

loop diuretic

11
Q

Most commonly used loop diuretic?

A

furosemide (lasix)

12
Q

effective at low glomerular filtration rates, quick, animal will pee after 20 minutes

A

furosemide

13
Q

2 main vet med diuretics

A

mannitol and furosemide

14
Q

thiazide diuretics

A

distal convoluted tubule, only 20% effective

15
Q

thiazide diuretics used often when loop diuretics have caused

A

proliferation of cells downstream (in DCT)

16
Q

increase reabsorption of Ca, helps with animals forming Ca stones

A

thiazade diuretics (hydrochlorothiazide)

17
Q

Which drug is a thiazide diuretic?

A

hydrochlorothiazide

18
Q

only mild diuretic affect, helps with hyperaldosteronemia

A

aldosterone antagonist

19
Q

which drug is aldosterone antagonist?

A

spironolactone

20
Q

diminishes the degree of K+ loss

A

spirolactone

21
Q

Carbonic anhydrase inhibitors

A

prevents formation of bicarb from h20 and C02 (pH regulation)
mild diuretic

22
Q

decrease secretion of H+ into urine, -> acidotic animal

A

CA inhibitors

23
Q

which drug is a carbonic anhydrase inhibitor

A

acetazolamide