Diazepam Flashcards
0
Q
Clearance rate
A
0.2-0.5 ml/kg/min
1
Q
Lipid soluble
A
Very lipid soluble
Rapid uptake by the brain
Large VD
2
Q
Half life
A
Long elimination half life
21-37 hours
Longer in elderly
Determined by metabolism and elimination
3
Q
Metabolized
A
Primarily in liver via oxidative N-demethylation
Hepatic clearance: bodily proportion of fatty tissue increases
Increases VD for lipid soluble drugs and takes longer to metabolize
4
Q
Desmethyldiazepam
A
Slightly less active than diazepam
Metabolized more slowly than diazepam
Oxazepam
Temazepam
5
Q
Cimetidine and diazepam
A
Delays hepatic clearance affects diazepam and desmethyldiazepam clearance
6
Q
Anesthetic effects of diazepam
A
Reduces the dose of induction agent
Reduces MAC of inhalation agent
7
Q
Reduction in MAC of halothane
A
0.2 mg/kg IV diazepam to 48%
