Diabetes Drugs (FA)

Question 1

What are the rapid acting insulins?

Answer 1

Lispro, Aspart, Gluisine

“No LAG in these drugs”

Question 2

What is the MoA of insulin drugs?

Answer 2

Same as endogenous: Bind insulin-R –> tyrosine kinase activity –> increase insulin release from B-cells

Question 3

What insulin analog is used in DKA?

Answer 3

Regular insulin IV

Question 4

What are the long acting insulin drugs?

Answer 4

Glargine, Determir

I’m GlaD this is finally working

Question 5

What is the first line for DM2?

Answer 5

Metformin, Mech unknown

Question 6

What is the contraindication of Metformin?

Answer 6

Renal failure

Question 7

What is the mechanism of sulfonylureas drugs?

Answer 7

Close K+ channels –> depolarize cell –> Ca++ influx –> insulin release

Question 8

“-Mide and -ide” drugs?

Answer 8

Sulfonylureases
First Generation ex. Tolbutamide
Second Gen. ex. Glimepiride

Question 9

What is the most commonly used Sulfylurease?

Answer 9

Glyburide

Question 10

What is the MoA of glitazones?

Answer 10

Bind PPAR-y muclear transcription –> increase insulin sensitivity

Question 11

What are the a-glucosidase inhibitors and their MoA?

Answer 11

Miglitol, Acarbose: inhibit a-glucosidases in intestines–> delay glucose absorption –> decrease postprandial hyperglycemia
- My Caboose: reminder of names and site of action and toxicity

Question 12

What is a unique side effect of glitazones?

Answer 12

Hepatotoxicicty

Question 13

What is sitagliptin and its MoA?

Answer 13

DDP-4 inhibitor used in DM2. Inhibits the breakdown of GLP –> incr. insulin release and decr. glucagon release