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Metabolism, Endocrinology and Haematology > Diabetes > Flashcards

Flashcards in Diabetes Deck (20)
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1
Q

Characterise both type 1 and type 2 diabetes

A

Type 1 - have progressive loos of all or most of the pancreatic B-cells

Type 2 - have slow progressive loss of B-cells along with disorders of insulin secretion and tissue resistance to insulin

2
Q

What causes the destruction of the B-cells in type 1

A

Immune activation produces killer lymphocytes, macrophages and antibodies that attck and progressively destroy B-cells

3
Q

Why does a type 1 diabetic get polyuria

A

Large quantities of glucose are filtered but not reabsorbed by the kidney

This glucose remains in the nephron tubule, placing an extra osmotic load on the nephron so less water is reabsorbed to maintain the isosmotic character of the section of the tubule

This extra water remains with the glucose and is excreted as copious urine

4
Q

What are the triad of symptoms of type 1 diabetes

A

Polyuria

Thirst

Weight loss

5
Q

What do you test for in type 1 diabetics

A

High blood glucose

Glycosuria - glucose in urine

Ketones in the urine

6
Q

What life threatening crisis can develop in type 1 diabetics if they are not treat

A

Diabetic ketoacidosis

7
Q

What are the symptoms of ketoacidosis

A

Prostration

Hyperventilation

Nausea

Vomiting

Dehydration

Abdominal pain

8
Q

How does type 2 diabetes present

A

May present with classical triad of symptoms

Lack of energy

Persistant infections

Infections of the feet

Slow healing

Minor skin damage

Visual problems

Typically no weight loss

9
Q

Describe the mechanisms of type 2 diabetes - what causes the patient to become insulin resistant

A

Defective insulin receptor mechanism - change in receptor number and/or affinity

Defective post-receptor events

Excessive or inappropriate glucagon secretion

10
Q

What is the HbA1c test and how is it used

A

Test to measure the amount of glycated Hb which reflects the average glycaemia over a period of week

Glucose reacts with terminal valine of Hb to produce glycated Hb

If it is above 6.5% then it indicates a poor plasma glucose control and possible diabetes

11
Q

How is diabetes diagnosed

A

Diagnosed in the presence of symptoms plus one of the following:

Random venous plasma glucose ≥ 11.1 mmol/L

Fasting plasma glucose ≥7.0mmol/L (whole blood ≥6.1)

Plasma glucose ≥11.1mmol/L 2 hours after 75g anhydrous glucose in oral glucose tolerance test (OGTT)

Or diagnosed using two of the tests with no symptoms

12
Q

What is the treatment for type 1 diabetics

A

Insulin injection either subcutaneously or by insulin pump

Insulin injection given at dose and time to mimic behaviour of islets

Regular meal times

Regular exercise

Test blood glucose regularly - carry around sweets/sugar to avoid hypoglycaemia

13
Q

What is the treament for type 2 diabetes

A

Treat with insulin if disease progresses that far

Treat with sulphonylureas - increase insulin release and reduce insulin resistance

Metformin - reduces gluconeogenesis

Dietary management

Exercise

14
Q

What are the metabolic consequences of persistant hyperglycaemia

A

Excess intracellular glucose is metabolised using aldose reductase:

Glucose + NADPH + H+ -> Sorbitol + NADP+

This reduces NADPH and leads to increased disulphide bond formation. Accumulation of sorbitol causes osmotic damage

Increased glycation of plasma proteins causing abnormal function

HbA1c increases

15
Q

What are the macrovascular complications of diabetes

A

Increased stroke risk

Increased MI risk

Poor circulation to periphery

16
Q

What are the microvascular complications of diabetes

A

Diabetic eye disease - diabetic retinopathy where there is damage to blood vessels in retina which can lead to blindness: vessels leak and form protein exudates on retina or vessels rupture and cause bleeding into eye

Diabetic kidney disease (nephropathy) - damage to glomeruli, poor blood supply or damaged by infections of urinary tract. Early sign is increased protein in urine

Diabetic neuropathy - diabetes damages peripheral nerves: loss of sensation, altered function of ANS producing changes

Diabetic feet - poor blood supply, nerve damage and increased infection risk make feet of diabetics vulnerable

17
Q

What is metabolic syndrome

A

Group of symptoms including:

Insulin resistance

Dyslipidaemia

Glucose intolerance

Hypertension associated with central adiposity

18
Q

What is metabolic syndrome caused by

A

Insulin resistance

Central obesity

Genetics

Physical inactivity

Aging

19
Q

How does insulin resistance develop into type 2 diabetes in the young

A

Initially B cells compensate by upregulating insulin production to maintain normal plasma glucose

Eventually B cell become unable to maintain increased insulin production so become incapacitated and no longer function leading to glucose intolerance

Finally B cell dysfunction leads to relative insulin deficiency and type 2 diabetes

20
Q

What are the symptoms and final stage of ketoacidosis

A

Symptoms:

Hyperventilation

Nausea

Vomiting

Abdominal pain

Finally: coma