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Basic Immunology- Module 1 > Dendritic Cells > Flashcards

Flashcards in Dendritic Cells Deck (55)
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1

What is the general function of NOD-like receptors?

intracellular sensors of bacterial infection and cellular damage

2

What is the general function of RIG-I-like receptors?

detect cytoplasmic viral RNAs

3

What pathway fo RIG-I-like receptors trigger?

MAVS

4

What is the function of activating MAVS pathway?

induce type 1 interferons and pro-inflammatory cytokine production

5

What is the special function of dendritic cells?

only true professional APC with ability to activate naive T cells

6

What cells are considered professional APCs?

B cells; macrophages and dendritic cells

7

What are hte features of dendritic cell biology which make it suited for initiating immune responses?

efficient at antigen presentation; accumulate within T cell areas of lymphoid organs and ability to polarise T cells

8

What is the dramatic structual reorganisation of dendritic cell maturation known as?

phenotypic maturation

9

What are the features of immature dendritic cells?

peripheral and lymphoid tissues; highly endocytic; low surface MHC-II and costimulators

10

What is the main function of immature DCs?

antigen accumulation

11

What is the main function of mature DCs?

T cell stimulation

12

What are the features of mature DCs?

foudn in lymphoid tissues; endocytosis reduced; high surface MHC-II and costimulators

13

What do DCs process antigens into for presentation?

proteolytic peptides

14

Where do DCs mature?

secondary lymphoid organs

15

What causes DCs to mature?

pathogen derived danger signals ; pathogen derived TLR ligands

16

What changes in the function of the DC in maturation?

peptide loading; half-life and delivery of MHC molecules is increased; costimulatory molecules increases

17

What is the proteolytic apparatus in the endosomal-lysosomal system?

cathepsins and other lysosomal hydrolases

18

what is the proteolytic system in the cytosol?

proteasome

19

What causes MHC class II molecules to be actively diverted to lysosmes in immature state?

ubiquitination

20

What is ubiquitination?

proces of attachment of one or many subunits of ubiquitin to a target protein

21

What is the function of ubiquitin?

functions as a protein interaction module or to target protein for degradation by the proteasome

22

What happens initially to endocytosis in a maturing DC?

upregulated- increase chance of capturing pathogen

23

What chemokine receptor is upregulated in maturing DCs?

CCR7

24

What receptors are involved in activating DC maturation?

toll-like receptors; cytokine receptors; TNF-receptor family; FcR; sensors for cell death

25

What do plasmacytoid DCs produce in response to viral stimuli?

IFNa

26

What is the function of receptor-mediated endocytosis?

allows uptake of macromolecules through specialised regions of hte plasm membrane-coated pits

27

What is found on the outside of endocytic vesicles used in receptor-mediated endocytosis?

clathrin

28

What is the binding of ligands to C-type lectins dependent on?

calcium

29

What is a Langerhan cell?

dendritic cell in the skin

30

What are C-type lectins important in the detection of?

fungi