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RUSVM Toxicology 2016 > DEET > Flashcards

Flashcards in DEET Deck (9)
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1
Q

What is a common use of DEET?

A

Insect repellant

2
Q

What is the Acute oral LD50 in rats for DEET?

A

2g/kg

3
Q

What is the acute dermal LD50 in rabbits for DEET?

A

3g/kg

4
Q

DEET toxicokinetics

A

Absorbed through the skin
can increase dermal absorption of other products
Metabolized inthe liver and excreted in urine

5
Q

What are the clinical signs of DEET?

A
Rats and Rabbits: 
Depression 
excitation 
ataxia 
tremors
seizures 
coma
Dogs and Cats: 
Salivation
Vomiting 
hyperexcitability 
tremors
ataxia 
seizures
6
Q

What should chemical analysis be used on to detect DEET?

A
stomach contents
urine 
blood 
skin 
vitreous humor 
bile 
kidney
7
Q

What is considered diagnostic for DEET?

A

20ppm
Urine concentrations greater than 1ppm
tissue greater than 10ppm

8
Q

Treatment for DEET?

A

No specific antidote
Decontamination: Emesis, Activated Charcoal
Symptomatic treatment

9
Q

What is the prognosis for DEET?

A

Good - respond in 24-72hours