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Cytokines > Cytokines > Flashcards

Cytokines Flashcards

1
Q

GM-CSF

A

Producing Cell: Th
Target Cell: progenitor cells
Function: Growth and differentiation of monocytes and DC

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2
Q

IL-1alpha and IL-1beta

A

Producing: monocytes, macs,bcells,DC
Target: Th cells, b cells, nk cells, inflammation, acute phase response, fever

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3
Q

Th cells do what?

A

co stimulation

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4
Q

Il-2

A

Producing: Th1 cells

Target Cell: Activated T and B cells, NK cells

Function: growth, proliferation, activation

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5
Q

IL-3

A

Producing: Th Cells and natural killer cells

Target cell:

  • Stem cell: growth and differentiation
  • Mast cell: growth and histamine release
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6
Q

Il-4

A

producing: Th2 cells

Target cell
-Activated B cell: proliferation and differentiation, IgG and IgE synthesis
-Macrophages: MHC Class II
T Cells: proliferation

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7
Q

IL-5

A

Producing: Th2
Target cells: activated B cell
to do proliferation and differentiation
IgA synthesis

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8
Q

IL-6

A

Producing: monocytes, macrophages, Th2 cells, stromal cells

Target cell:

  • Activated B cells: differentiation into plasma cells
  • Plasma Cells: antibody secretion
  • Stem cells: differentiation
  • Various: acute phase response
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9
Q

IL-7

A

Producing cell: marrow stroma and thymus stroma

Target: stem cells to differentiation into progenitor B and T cells

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10
Q

IL-8

A

Producing: macrophages and endothelial cells

Target: neutrophils to do chemotaxis

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11
Q

Il-10

A

Producing cell: Th2

Target

  • Cell: macrophages: cytokine production
  • b cell activation
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12
Q

IL-12

A

Producing cell: macrophages and B cells

Target:

  • activated T cells: differentiate into CTL(cytotoxic t lymphocytes) (with Il-2)
  • NK cell activation
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13
Q

IFN-alpha

A

Producing cell: leukocytes

Function: Various: viral replication and MHC I expression

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14
Q

IFN-beta

A

Producing cell: Fibroblasts

Function: various viral replication and MHC I expression

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15
Q

IFN-gama

A

Producing cell: TH1, Tc cells, NK cells

Function:

  • viral replication
  • Macrophages: MHC expression and pathogen elimination
  • Ig class switch to IgG2a
  • Th2 cells: proliferation
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16
Q

MIP-1alpha

A

Producing cell: macrophages

Function:
-monocytes,T cells: chemotaxis

17
Q

MIP-1beta:

A

Producing cell: lymphoctes

Function: monocytes and T cells: chemtaxis

18
Q

TGF-beta

A

Producing cell: T cells, monocytes

Function:

  • monocytes and macrophages: chemotaxis
  • Activated Macrophages: Il-1 synthesis
  • Activated B cells: IgA synthesis
  • Proliferation
19
Q

TNF-alpha

A

Producing cell: Macrophages, mast cells, NK cells

Function:

  • Macrophages: CAM and cytokine expression
  • Tumor Cells: cell death
20
Q

TNF-Beta

A

Producing cell: Th1 and Tc cells

Function:

  • phagocytes: phagocytosis, NO production
  • Tumor cells: cell death

Cytokines (9 decks)

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