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Flashcards in CSF Analysis Deck (24)
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1
Q

autoimmune disease of the CNS

A

ALS
SLE
MS (demyelinating disorders)
Neurosyphilis

2
Q

how do you obtain CSF?

A

lumbar puncture from subarachnoid space

3
Q

where is the CSF produced?

A

choroid plexus of the ventricles

4
Q

what are the roles of CSF?

A

transports nutrients

clears metabolic waste

5
Q

what could blood in the tap indicate?

A

subarachnoid hemorrhage will not clot

traumatic tap will clot

6
Q

what could cloudy CSF mean?

A

presence of WBC or protein

7
Q

what could xanthochromia of the CSF mean?

A

yellow tinge
hyperbilirubinemia
hypercarotenemia
melanoma

8
Q

elevated PMNs means

A

bacterial meningitis or cerebral abscess

9
Q

what 4 tubes do you send in a CSF analysis?

A

culture
cell count, cytology
pH, protein, glucose, chloride
serology

10
Q

common bacterial meningitis causers

A

H. influenzae
neisseria meningitis
S. pneumonia

11
Q

common viral meningitis causers

A

herpes simplex
coxsackiervirus
echovirus
infectious mono

12
Q

should protein be in CSF?

A

no, BBB should not allow it to cross

some disease can alter the permeability and allow protein to leak into the CSF

13
Q

why is glucose important to the brain?

A

brain doesn’t produce or store its own glucose

14
Q

how do bacteria, inflammatory cells, and tumors impact glucose in CSF?

A

decreased

15
Q

how do you test CSF glucose?

A

compare to serum glucose (drawn prior to LP)

should be >60% of serum

16
Q

how will bacteria and fungal infection impact lactic acid in CSF?

A

increased

indicates decreased oxygenation of the brain-anaerobic metabolism

16
Q

which tests identify syphilis?

A

Wasserman
Venereal Disease Research Lab test
Fluorescent Treponamal antibody (most spec and sens)

17
Q

how is chloride level different in the CSF?

A

it is higher

18
Q

what type of white blood cell is normally in the CSF?

A

lymphocyte mostly

19
Q

what would presence of mononuclear leukocyte indicate?

A

viral
TB
encephalitis

20
Q

how will infection or TB affect chloride levels?

A

decrease

21
Q

how would infection or inflammation impact LD levels?

A

increase (comes from WBC that are fighting bacteria)

22
Q

what level might be low when lactic acid level is high?

A

glucose level

23
Q

what other test is useful for the diagnosis of bacterial meningitis?

A

CRP of serum (sensitive)

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