Concerns for the use of soy-based formulas in infant nutrition Flashcards Preview

SB_CPS Statements (Pediatrics Royal College 2018) > Concerns for the use of soy-based formulas in infant nutrition > Flashcards

Flashcards in Concerns for the use of soy-based formulas in infant nutrition Deck (9)
Loading flashcards...
1
Q

What are phytoestrogens?

A

Plant derived substances with estrogenic activity

2
Q

What type of estrogen are contained in soy-based infant formulas?

A

Isoflavone class, which includes genistein, daidzein, glycitein

3
Q

What is the potency of isoflavones?

A

Relatively weak estrogens. ~1/1000-1/10 0000 of potency of estradiol.

4
Q

What is the daily intake of phytoestrogens consumed by infants on soy-based formula?

A

4-11mg/kg body weight

13 000-22 000 times greater than [plasma estradiol]

5
Q

What percentage of phytoestrogens in soy-based infant formulas are present in biologically inactive form?

A

94%

6
Q

What are contraindications to the use of soy based formula

A
  1. Congenital hypothyroidism - as inhibits thyroid peroxidase lowering free thyroxine
  2. Premature infants - as provides inadequate nutrition and growth
7
Q

What are some concerns noted with isoflavones from soy based formulas in animal studies?

A
  1. sex organ development
  2. brain maturation
  3. immune system function
  4. stimulate cancer development
  5. infertility
8
Q

Why should soy based formula not be used in CMPA?

A

Coincident soy protein allergy

7-14% in IgE mediated, higher in non-IgE mediated

9
Q

What are indications for soy based formulas?

A
  1. Galactosemia

2. Cannot consume dairy based products for cultural or religious reasons

Decks in SB_CPS Statements (Pediatrics Royal College 2018) Class (223):