Flashcards in Component Therapy / Test 3/3 Deck (76)
What is the concept of component administration ?
use particular component for specific need
What ate the advantages of specific component administration ?
conserve blood, facilitate optimum treatment
Blood can be separated into what other components?
- Approximately 400-550 ml plus
- 63 ml of CPD (anticoagulant)
- Hematocrit (HCT) – 36-44%
WHOLE BLOOD is stored at 1-6 C.
What beomes non functional ?
What factors decrease during storage?
Factors V and VIII
What are 3 Indications for Whole Blood ?
- Oxygen-carrying capacity / blood volume expansion
- Stable coagulation factors.
- Actively bleeding with > 25% blood loss
What is the best solution of the storage of whole blood ?
CPDA – 35 day outdate
Dose and administration of whole blood (adult) & (Peds)?
1g/dL Hgb or 3% Hct increase (adults)
8mL/kg – 1g/dL Hgb increase (peds)
Whole blood must be Administered through a blood filter within ?
Hematocrit of the donor unit is ?
Dose and administration of whole blood (neonates?
10 – 15 mL/kg will increase the hemoglobin by about 3 g/dL
RED BLOOD CELLS Prepared from whole blood: What is the Hct range for (AS red cells) ?
RED BLOOD CELLS Prepared from whole blood: What is the Hct range for (CPDA-1) & (CPD) ?
What is the residual plasma content in RBC units?
~20 – 120 mL
Why would you transfuse RBCs ??
Increase oxygen carrying capacity and red cell mass
General guidelines for RBC transfusion for patients that have a Hgb > 10g/ml ?
increased oxygen consumption, e.g. sepsis
Signs and symptoms supporting need for transfusion
of RBC ?
-Rapid fall in Hgb (active bleeding)
Medical condition influencing need for transfusion of RBCs ?
-Acquired or congenital anemias
You should NEVER hang RBCs with what other infusions ?
-LACTATED RINGERS OR
What other infusions CAN you hang RBCs with ?
In Order to transfuse RBCs ABO and Rh must be compatible, you should transfuse over a period of ?
4 hrs with a filter
Regular PRBCs contain how many WBC ?
1-3x 10^9 WBC/unit
Leukoreduced units must retain what percentage of RBCs after filtration?
3 reasons of why we should use Leukoreduced PRBCs ?
-Prevent febrile nonhemolytic reactions
-Reduce HLA alloimmunization
-Prevent TA-CMV infection
Some patients may actually produce leukoagglutinins after many transfusions or just a few. The patient produces antibodies that will bind to the transfused leucocytes and the resulting complexes bind to and activate monocytes which release what?
cytokines with pyrogenic properties.
RED BLOOD CELLSWASHED with NS ?
98% plasma free
Reduced leukocytes, platelets
24 hour shelf life
10-20% red cell loss
Why would we transfuse washed RBCs ?
Prevent recurrent/severe allergic reactions to plasma proteins
When RED BLOOD CELLS are Frozen and deglycerolized for Long term preservation
what do we add as a cryoprotectant ?
When RED BLOOD CELLS are Frozen and deglycerolized they can be stored at -65 c for how long ?