Component Therapy / Test 3/3 Flashcards Preview

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Flashcards in Component Therapy / Test 3/3 Deck (76)
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1

What is the concept of component administration ?

use particular component for specific need

2

What ate the advantages of specific component administration ?

conserve blood, facilitate optimum treatment

3

Blood can be separated into what other components?

Packed cells
Plasma
Platelets
Cryoprecipitate

4

WHOLE BLOOD

- Approximately 400-550 ml plus
- 63 ml of CPD (anticoagulant)
- Hematocrit (HCT) – 36-44%

5

WHOLE BLOOD is stored at 1-6 C.

What beomes non functional ?

What factors decrease during storage?

platelets/granulocytes

Factors V and VIII

6

What are 3 Indications for Whole Blood ?

- Oxygen-carrying capacity / blood volume expansion
- Stable coagulation factors.
- Actively bleeding with > 25% blood loss

7

What is the best solution of the storage of whole blood ?

CPDA – 35 day outdate

8

Dose and administration of whole blood (adult) & (Peds)?

1g/dL Hgb or 3% Hct increase (adults)

8mL/kg – 1g/dL Hgb increase (peds)

9

Whole blood must be Administered through a blood filter within ?

4 hrs

10

Hematocrit of the donor unit is ?

60%

11

Dose and administration of whole blood (neonates?

10 – 15 mL/kg will increase the hemoglobin by about 3 g/dL

12

RED BLOOD CELLS Prepared from whole blood: What is the Hct range for (AS red cells) ?

(Hct 50-65%)

13

RED BLOOD CELLS Prepared from whole blood: What is the Hct range for (CPDA-1) & (CPD) ?

(Hct 65-80%)

14

What is the residual plasma content in RBC units?

~20 – 120 mL

15

Why would you transfuse RBCs ??

Increase oxygen carrying capacity and red cell mass

16

General guidelines for RBC transfusion for patients that have a Hgb > 10g/ml ?

increased oxygen consumption, e.g. sepsis

17

Signs and symptoms supporting need for transfusion
of RBC ?

-Syncope
-Angina
-dyspnea
-Tachycardia
-Rapid fall in Hgb (active bleeding)

18

Medical condition influencing need for transfusion of RBCs ?

-CHF
-Coagulopathy,
-DIC
-Acquired or congenital anemias

19

You should NEVER hang RBCs with what other infusions ?

-D5W,
-LACTATED RINGERS OR
-MEDICATIONS

20

What other infusions CAN you hang RBCs with ?

-NS,
-albumin or
-plasmanate

21

In Order to transfuse RBCs ABO and Rh must be compatible, you should transfuse over a period of ?

4 hrs with a filter

22

Regular PRBCs contain how many WBC ?

1-3x 10^9 WBC/unit

23

Leukoreduced units must retain what percentage of RBCs after filtration?

85%

24

3 reasons of why we should use Leukoreduced PRBCs ?

-Prevent febrile nonhemolytic reactions
-Reduce HLA alloimmunization
-Prevent TA-CMV infection

25

Some patients may actually produce leukoagglutinins after many transfusions or just a few. The patient produces antibodies that will bind to the transfused leucocytes and the resulting complexes bind to and activate monocytes which release what?

cytokines with pyrogenic properties.

26

RED BLOOD CELLSWASHED with NS ?

70-80% Hct
98% plasma free
Reduced leukocytes, platelets
24 hour shelf life
10-20% red cell loss

27

Why would we transfuse washed RBCs ?

Prevent recurrent/severe allergic reactions to plasma proteins

28

When RED BLOOD CELLS are Frozen and deglycerolized for Long term preservation
what do we add as a cryoprotectant ?

glycerol

29

When RED BLOOD CELLS are Frozen and deglycerolized they can be stored at -65 c for how long ?

10 yrs

30

When RED BLOOD CELLS have been Frozen and deglycerolized, and now we need to use them, what do we do ?

-Thaw and wash with saline/glucose solution

-Maintain 70-80% Hct
-24 hour shelf life