Common rat strains and research uses Flashcards Preview

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Flashcards in Common rat strains and research uses Deck (24)
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1

ACI

  • High incidence of urogenital congenital malformations including renal agenesis, hypoplasia, hydronephrosis or cystic kidney, unilateral, that may be associated with ipsilateral defective uterine horn or testis
  • High incidence of testicular tumors

2

BB/Wor

  • Type I DM: juvenile onset 

3

BN

Brown Norway

  • Transplantation research: inducible, transplantable myeloid leukemia, bladder carcinoma
  • Hydronephrosis
  • Genetic mapping, respiratory inflammation, immunological dysfunction, aging

4

BUF

Buffalo Rat

  • Spontaneous autoimmune thyroiditis
  • Carcinogenesis & oncology - host for transplantable Morris hepatoma

5

COP

Copenhagen Rat

  • Carcinogenesis research & oncology
  • Protate adenocarcinoma

6

F-344

Fischer 344

  • Inbred rat model for National Toxicology Programs Carcinogen Bioassay Program and the National Institute of Aging
  • General multipurpose model, aging, safety and efficacy testing, surgical model, oncology, nutrition
  • High rate of spontaneous cancer

7

LEW

Lewis Rat

  • Multiple sclerosis & various experimentally induced autoimmune diseases
    • Induced arthritis/inflammation
    • Experimental allergic encephalitis
  • STZ-induced diabetes
  • Transplantation research

8

LOU/C

  • High incidence of myeloma/plasmacytoma
  • Production of IgG autoantibody

9

SHR

What is the control for this rat?

Spontaneous Hypertensive Rat --> WKY is the control strain in studies using SHR 

  • Hypertension & CV research: genetic hypertension, hypertensive drug research
  • ADHD model, safety and efficacy testing

10

WF

Wistar-Furth

  • Mononuclear cell leukemia
  • Resistant to chronic renal disease
  • Macrothrombocytopenia model
  • Oncology & carcinogenesis
  • Grand mal seizure

11

ZDF

Zucker Diabetic Fatty

  • Obese, type II DM & metabolic syndrome
    • Obesity
    • Insulin resistance (hyperinsulinemia)
    • Glucose intolerance (hyperglycemia)
    • Dyslipidemia (hypertriglyceridemia, hypercholesterolemia)
    • Hypertension
  • Nephropathy, impaired wound healing, & neuropathy

12

Battleboro

  • Diabetes insipidus
    • autosomal recessive

13

Gunn

  • Jaundice & kernicterus (bilirubin-induced brain injury)
    • Lacks UDP glucuronyl transferase in liver
  • Model of Crigler-Najjar Syndrome

14

RNU

What is the genotype & phenotype?

Rowett Nude Rat...aka...Nude Rat, Athymic Rat

  • Genotype = Foxn1rnu / Foxn1rnu 
  • Phenotype = T cell-deficient, B cells & NK cells are present

15

SHROB

Spontaneously Hypertensive Obese Rat

  • Metabolic Syndrome
    • Hypertension
    • Insulin resistance
    • Glucose intolerance
    • Obesity
    • Hyperlipidemia: Type 4 hyperlipoproteinemia
  • Nephropathy

 

16

GK (Goto-Kakizaki)

  • Non-obese  type 2 DM
  • Wistar substrain that develops adult onset DM early in life

17

Zucker

Obesity & metabolic syndrome

 

18

Dahl/SS

What is the control for this rat?

Dahl/Salt Sensitive Rat

The SS-13BN is the normotensive control for the Dahl/SS rat

  • Hypertension 
  • Diastolic heart failure
  • Nephropathy

.

19

FHH

Fawn hooded rat

  • Hypertension & pulmonary hypertension
  • Nephropathy
  • Alcohol consumption

20

LEC

Long Evans Cinnamon

  • Model of spontaneous hepatitis and liver cancer d/t abnormal copper metabolism 
  • Wilson's Disease

21

WAG/Rij Rat

Wistar Albino Glaxo Rat

  • Bilateral retinal degeneration resembles human retinitis pigmentosa
  • L4415 leukaemia in the WAG/Rij is an animal model for the human acute lymphocytic leukaemia

22

Spotted lethal mutant

  • Aganglionic megacolon
  • Model of Hirschsprungs Disease in humans
    • Similar to Lethal White Syndrome most common in American Paint Horses
  • The coat is completely white (unpigmented) except for a pigmented spot on head

23

LES & LE-bo

Long Evans Shaker & Long Evans Bouncer

Models of dysmyelination

Prone to seizures which can cause hyperflexion of spine leading to acute hindlimb paralysis

LE-bo presents earlier & has a shorter lifespan

 

24

WBN/Kob

Wistar Bonn Kobori

Type I diabetic rats that spontaneously develop diabetic peripheral motor neuropathy