Coagulation/Anticoagulation and Hemorrhagic/Thrombotic Disorders Flashcards Preview

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Flashcards in Coagulation/Anticoagulation and Hemorrhagic/Thrombotic Disorders Deck (122)
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1

Ability of the body to stop bleeding from a damaged vessel and to repair the defect such that normal blood flow to the involved area is restored

Hemostasis

2

__ domain contains N-terminal domain of all polypeptides

E

3

______ can also bind IXa (less affinity) to form a TFPI-IXa-TF-VIIa complex

TFPI

4

______ can bind to Xa at its active site, and the TFPI-Xa complex inactivates TF-VIIa

TFPI

5

______ cleaves fibrinogen and fibrin to form FDP (Fibrin Degradation Products)

Plasmin

6

______ cleaves fibrinogen to fibrin and activates XIII to XIIIa

Thrombin

7

______ is a cofactor for APC cleavage of Va and VIIIa.

Protein S

8

______ is the only Vitamin-K dependent factor that is not a serine protease

Protein S

9

______ on the platelet surface interact with collagen, laminin, and fibronectin

Beta-1 integrins

10

______ removes basic amino acids from the C-terminal end of fibrin, reducing plasminogen binding sites on fibrin

Thrombin-activatable fibrinogen inhbitor (TAFI)

11

_______ consists of central globule (__ domain) and globules on each end of the molecule (__ domains)

Fibrin, E, D

12

_______ activates V and VIII to Va and VIIIa

Thrombin

13

_______ cleaves and inactivates factors Va and VIIIa, resulting in decreased thrombin production

APC

14

_______ covalently crosslinks adjacent D domains to stabilize/strengthen the clot

XIIIa

15

_______ Factor adheres to exposed, damaged, subendothelium

von Willebrand

16

_______ hemostasis: activation of clotting cascade and formation of fibrin clot

Secondary

17

_______ hemostasis: platelet adhesion, aggregation, and activation

Primary

18

_______ increases release of vWF from endothelium

Arginine vasopressin

19

_______ inhibits extrinsic part of coagulation pathway/initiation phase

Tissue Factor Pathway Inhibitor (TFPI)

20

_______ is resistant to proteolytic action of APC

Factor V Leiden

21

_______ measures the extrinsic pathway

PT

22

_______ measures the intrinsic pathway

PTT/APTT

23

________: antibodies interfere with function of phospholipid-binding proteins involved in regulation of coagulation

Antiphospholipid Antibody Syndrome

24

_______: can lead to heparin resistance because heparin is a cofactor for antithrombin

Antithrombin Deficiency

25

_______: IgG antibody against phospholipid in the platelet membrane, causing Antiphospholipid Antibody Syndrome (APS)

Lupus Anticoagulant

26

_______: internal membrane tunnels though which contents of granules can be released

Canalicular System

27

_______: leads to elevated concentration of plasma prothrombin, autosomal dominant inheritance

Prothrombin mutation

28

_______: leads to partial resistance to inactivation via Protein C proteolytic cleave

Factor V Leiden

29

_______: mutation in Factor V with an autosomal dominant inheritance pattern

Factor V Leiden

30

______: activated reaction of plasma with an anionic substrate

APTT