Coagulation Flashcards Preview

Dental Pharmacology > Coagulation > Flashcards

Flashcards in Coagulation Deck (26)
Loading flashcards...
1
Q

intrinsic anticoagulants

A

protrombin III, protein C, protein S

2
Q

fibrinogen to fibrin is the … step

A

last

3
Q

… activation is a critical step and is dependent upon either activation by factor IXa and VIIa or by factor VIIa

A

factor X

4
Q

… degrades fibrin to fibrin degradation products

A

plasmin

5
Q

Factors II (prothrombin), V, VII, IX, and X are synthesized in the …

A

liver

6
Q

… required for gamma-carboxylation of glutamic acid in factors II, VII, XI, and X

A

vitamin K

7
Q

… does not require gamma-carboxylation

A

factor V

8
Q

binds to antithrombin III and increases activity 1K fold

A

heparin

9
Q

antibodies can form against the complex of …

A

heparin-platelet factor 4

10
Q

smaller, active pieces of regular heparin; greater anti-Xa activity, less antiplatelet activity

A

low molecular weight heparin

11
Q

inhibit thrombin w/o antithrombin III; inhibit thrombin-mediated activation of clotting factors and platelets; action against free and clot-bound thrombin; doesnt induce immune-mediated thrombocytopenia

A

direct thrombin inhibitors

12
Q

direct thrombin inhibitor; found in salivary glands of the medicinal leech; irreversible binding at active site

A

hirudin

13
Q

DTIs with reversible binding at active site

A

bivalirudin, argatroban, melagtran

14
Q

heparin only has action against … thrombin

A

free

15
Q

indirect factor X inhibitors

A

LMW heparins

16
Q

only been approved for DVT; bind to factor X directly and inhibit proteolytic activity to convert prothrombin to thrombin

A

direct factor Xa inhibitors

17
Q

vitamin K epoxide reductase is required to reduce vit. K at 2 stages, … binds to the reductase and blocks its activity

A

warfarin

18
Q

slow onset warfarin is usually administered with another fact acting anticoagulant such as ….

A

heparin

19
Q

irreversible COX inhibitor that prevents thromboxane formation

A

aspirin

20
Q

prevents ADP binding and prevents the appearance of GPIIb/IIIa receptors on platelet surface

A

clopidigrel

21
Q

prevent binding of fibrinogen to platelets

A

GPIIb/IIIa receptor antagonists

22
Q

agents that increases platelet cAMP … aggregation

A

inhibit

23
Q

mimic effects of tissue plasminogen activating factor

A

thrombolytic agents

24
Q

tissue plasminogen activating factor can only activate when bound to …

A

fibrin

25
Q

route of clearance of all thrombolytic agents

A

liver

26
Q

only thrombolytic agent with indirect fibrin specificity/plasminogen activation

A

streptokinase