Chemotherapy I Introduction Flashcards Preview

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Flashcards in Chemotherapy I Introduction Deck (10)
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1
Q

What is the general rule for clinical detectability of cancers/tumors?

A

Greater than 30 doublings

2
Q

What is the #1 factor preventing curative treatment form chemotherapy?

A

Drug resistance of the tumors

3
Q

What are the 3 basic stages of cancer?

A
  1. Cancer localized to the organ of origin
  2. Cancer localized to the organ of origin with spread to the regional draining lymph nodes
  3. Disseminated disease
4
Q

What is the Skipper Hypothesis?

A

The ability of chemotherapy to cure is inversely proportional to the tumor burden - the more tumor cells, the less chance there is to cure.

5
Q

Chemotherapy

A

Drugs developed/designed/selected to kill mammalian cells

6
Q

What is the general purpose of Phase I trials?

A

Determine dose and dose limiting toxicity

7
Q

What is the general purpose of Phase II trials?

A

Determine activity of the drugs

8
Q

What is the general purpose of Phase III trials?

A

Determine efficacy of drugs

9
Q

What are the general SE of chemotherapy?

A
  • Fatigue
  • Nausea/vomiting
  • Loss of appetite
  • Alopecia
  • Myelosuppression
  • Sore mouth
10
Q

Vesicant

A

Substance that causes tissue blistering

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