Chemo Drugs 2 Flashcards Preview

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Flashcards in Chemo Drugs 2 Deck (13)
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1
Q

Imatinib

  • Mech
  • Target+Fxn (2)
  • Disease
  • Special
A

TK Inhibitor

  • Catalytic clef on ABL-binds and prevents fusion to resul tin in cytogenetic remission
  • Inhibits PDGFR and cKIT

CML (9,22 Philly Chrom)

Mutations in cleft limit ability of Imatinib to bind

2
Q

ATRA

  • Same mech @
  • Target/Mech
  • Disease
  • Special
A

Arsenic

Displaces PML-RAR (15;17) fusion protein-get differentation and death of these cells

Acute promyelocytic leukemia

ATRA Syndrome-occurs shortly after iniation

  • High neutrophil count
  • Capillary leak-pulm edemia=resp failure
  • renal failure
  • trx with steroids, chemo, or sup care
3
Q

Rituximab

  • Mech
  • Target
  • Disease
  • Special
A

Chimeric monoclonal Ab-immune activation

CD20 pre B and mature B cells

B cell malignancies (primary trx B cell NHL)

Also widely used in autoimmune diseases

4
Q

Crizotinib

  • Mech
  • Target
  • Disease
A

TK inhibitor

ALK, ROS1, HGFR

Anaplastic large T cell lymphoma

5
Q

Thalidominde

  • Disease
  • Special
A

Multiple myeloma

Teratogenic-focomelia

6
Q

Trastuzumab

  • aka
  • target
  • mech (2)
  • tox
A

Herceptin

HER2-R

Prevents dimerization which would result in proliferation signals
Ab depnendt cellualr cytotox

cardiac tox

7
Q

Cetuximab

  • mech
  • target
  • Special
A

Chimeric monoclonal Ab

EGFR

Resitance with K-RAS and BRAF mutations

8
Q

Erlotinib

  • Mech
  • Target
A

TK inhibitor

EGF-R activating mutations

9
Q

Bevacizumab

  • Target
  • Mech
  • Tox (4)
A

VEGFR

Inhibits VEGFR (which induces prolferation…)

Pulm hemorrhage-high risk in pts with squamous cell cancer
HTN
Proteinuria
100k cost

10
Q

Vemurafinib

  • Mech
  • Target
  • Disease
  • Tox
  • Special
A

Small molecule RAF inhibitor

V600 BRAF mutation (activates EGFR and AKT)

Melanoma, NHL, Hairy Cell Leukemia

Causes other skin cancers (need to give MEK inhibitor)

REsistance in colon cancer with V600E mutation

11
Q

Bortezomib

  • Target
  • Disease
  • Tox (2)
A

Proteosome Inhibitor (Ab?)

Primary trx for multiple myeloma

Neuropathy
Myelosupression

12
Q

Nivolumab

  • Target
  • Mech
  • Disease
  • Tox
A

PD-L1 inhibitor

PD-1-R-inhibits interaction with tumor PD-L1 which usually inhibits cell death by hiding from immume regulaation and antitumor responmse

HL

Immune mediated pneumonitis, colitis, hepatitis, endocrinopathies
Fatiue, rash, MSK pain, pruritis

13
Q

Do chemo man again

A

suh dude