Chapter 8 BNF (Malignant Diseases) Flashcards Preview

A - Pre Reg COPY > Chapter 8 BNF (Malignant Diseases) > Flashcards

Flashcards in Chapter 8 BNF (Malignant Diseases) Deck (27)
Loading flashcards...
1
Q

What are the side effects of Azathioprine and mercaptopurin?

A

Hypersensitivity (stop)

Bone marrow suppression (pre treatment screen for thiopurine methyl transeferases, low = high risk)

2
Q

How does allopurinol interact with azathioprine?

A

Inhibits it’s metabolism, reduce azathioprine dose

3
Q

What are the side effects of mycophenolate mofetil?

A

Hypogammaglobinanaemia

Bronchistatis

Bone marrow suppression

4
Q

How should contraception be used with mycophenolate mofetil?

A

6 weeks after discontinuing - women

Confirms until 90 days after discontinue - men

5
Q

Name a calcineurin inhibitor?

A

Tacrolimus

6
Q

What are the counselljng points with tacrolimus and ciclosporin?

A

Avoid sunlight
Avoid high potassium
Grapefruit juice

7
Q

What is the MHRA on tacrolimus and ciclosporin?

A

Maintain same brand

8
Q

How should Cytotoxics be prescribed, dispensed and administered?

A

According to written protocol or treatment plan

9
Q

Which Cytotoxics cause permanent male sterility?

A

Alkylating drugs and procarbazine

10
Q

What is tumour lysis syndrome and what are the clinical features?

A

Rapid destruction of malignant syndrome

Hyperkalaemia
Hyperuria
Hyperphosphotaemia
Hypocalcaemia

11
Q

What patients are at risk of tumour lysis syndrome?

A

Renal impairment
Dehydration
Hyperuricaemia

12
Q

Which cancer drugs increase risk of thromboembolism?

A

Cancer itself is a risk factor

Tamoxifen, thalidomide, linaclamide

13
Q

How is methotrexate induced mucocitis treated?

A

Folinic acid

14
Q

How is urothelial toxicity treated in cancer?

A

Mesna

15
Q

Which Cytotoxics do not cause bone marrow suppression?

A

Vincristine / Bleomycin

FBC before treatment

16
Q

How is bone marrow suppression treated?

A

Withdraw or reduce dose

17
Q

How is fever with neutropenia treated

A

Broad spectrum antibiotic / fligrastam

Avoid paracetamol

18
Q

How is hyperuricaemia treated in cancer?

A

Allopurinol 24 hrs before treatment

Febuxostat: 2 days before If allopurinol is CIed

Rasburicase: hyperuricaemia with blood cancer

19
Q

How is anticipatory acute and delayed nausea and vomiting treated?

A

Anticipatory: lorazepam

Acute: Dexamethasone, lorazepam, 5HT3 antagonist, aprepitant + Dexamethasone

Delayed: Dexamethasone and 5HT3, Dexamethasone and Aprepitant

20
Q

What are the types of Cytotoxic antibiotics?

A

Antracylines - doxorubicin

Antineoplastic antibiotics - Bleomycin

21
Q

What are the side effects of doxorubicin?

A

Cardiotoxicity

Red urine

22
Q

What are the advantages and disadvantages of liposomal doxorubicin?

A

Advantages - reduction of cardiotoxicity and extravation

Disadvantage: hand and food syndrome

23
Q

How is hand and foot syndrome from liposomal doxorubicin treated?

A

Cooling hands for 4/7 days

24
Q

How are anthracycline side effects and overdose treated?

A

Dexrazoxane

25
Q

What are the side effects of Bleomycin?

A

Pulmonary
Respiratory failure
Hypersensitivity
Dermatological toxicity

26
Q

How are vinca alkaloids administered ?

A

IV

27
Q

What are the side effects of Vinca alkaloids?

A

CNS toxicity