Flashcards in Chapter 6 Health Surveillance and Quality Assurance Deck (45)
An animal supplier's health status report is an assurance that the animal received in the facility is healthy and free of pathogens
Sentinel animals should be at least what age?
Which test detects known DNA sequences characteristic for the pathogen?
Polymerase chain reaction
Who decides which specific pathogens will be surveyed for in the animal facility?
Veterinarian, with input from the research team
How soon after exposure should a sentinel animal be tested for a specific pathogen?
3 to 6 weeks after exposure
Which pinworm infection can be detected by a tape test?
The presence of most bacteria can be confirmed by culture on artificial media
The pinworm Aspiculuris tetraptera
can be detected in mice by the anal tape test
What does the acronym MFI stand for?
Multiplex fluorescent immunoassay
In animal rooms where microisolation cages are being used, the sentinels are housed in cages that contain what item from other cages in the room?
If an animal tests negative for a pathogen 3 weeks after arrival at the facility, which conclusion can be drawn?
The animal was free of the pathogen when shipped
Serology is the best method to detect pathogens in immunodeficient animals.
The sentinel program detects mostly pathogens spread by fecal-oral contamination
Sentinel animals are experimental animals subjected to extra testing during the course of the study.
The best time to monitory for microbial antibodies is when the animals are very young.
Which activity must be done regularly in order to maintain the water quality in automatic watering systems?
-Flush cage rack water lines
-change in-line water filters
-Sanitize water lines and connectors
Which of the following can be consequence of the introduction of insects or rodents in the facility?
-Damage to electrical cords
-Compromised experimental data
Which type of feed is most likely to be used by a facility that must meet GLP standards?
Which of the following is a contaminant that can be found in automatic watering systems?
Any feed can be autoclaved without loss of nutrients.
Technology using adenosine triphosphate (ATP) test swabs uses (BLANK) to measure organic residue.
Which of the following is NOT provided by data obtained from microbial monitoring?
Confirmation of the validity of study results
What does the acronym "CFUs" stand for?
Colony forming units
What is contained in the paper strips used to test sanitation during autoclaving?
In addition to using tapes that indicate if the proper temperature was reached, cage washer effectiveness should be tested periodically for the presence of pathogens.
Which statement regarding testing water bottles for bacterial colonies is FALSE?
Enteric pathogens are unlikely to be found in used water bottles
All of the following can be increase a rodent's susceptibility to infectious, toxic, and other harmful agents, EXCEPT which of the following?
Extra environmental enrichment
Noise level above 85 decibels may cause which of the following effects?
-Auditory effects in rodents
-A rise in blood pressure in nonhuman primates
-Auditory effects in humans
Radios should no be permitted in any room where animals are housed.