Chapter 21 - Musculoskeletal And Anti-inflammatory Drugs Flashcards Preview

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(P. 403 and 584)

Medication used to relieve inflammation.

• In this chapter, anti-inflammatory drugs are used to treat disorders in which the musculoskeletal system is not functioning properly because of inflammation.


musculoskeletal conditions with inflammation:

(P. 403)

• arthritis
• bursitis
• spondylitis
• gout
• muscle strains
• sprains

☆ can cause swelling, redness, heat, pain, and limited muscle and joint mobility.


Neuromuscular blocking agents (NMBAs)

(P. 403)

Used during surgical, endoscopic, or Orthopedic procedures.

• These drugs are potentially very dangerous and can result in respiratory arrest because of potential to paralyzed the major muscle of ventilation, the diaphragm.

☆ these are administered only by anesthesiologists or specially trained Personnel skilled in intubation, medically induced paralysis, and resuscitation.


Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

(P. 403-404)

Such as ibuprofen, inhibit the synthesis of prostaglandins, substances responsible for producing much of the inflammation and pain of rheumatic conditions, sprains, and menstrual cramps.



(P. 408-409)

(Porous Bone) is defined as a systemic skeletal disease characterized by low bone mass and deterioration of bone tissue, leading to Bone fragility and entry susceptibility to fracture, especially of the hip, spine, and wrist.


Osteoporosis therapy

(P. 408-409)

Includes calcium and vitamin D supplementation and several prescription medications currently approved for the prevention and or treatment of osteoporosis.


Hormone replacement therapy (HRT)

(P. 410)

Estrogen with or without progestin -- is recommended for postmenopausal osteoporosis prevention secondary to estrogen deficiency only when the patients are unable to take other agents and when the benefits outweigh risks.

• the FDA recommends prescribing the lowest possible dose for the shortest period of time.

☆ If HRT is started soon after menopause, estrogen prevents The Accelerated phase of the bone loss that occurs in the first 5 years after the onset of menopause.


Skeletal muscle relaxants

(P. 401 and 594)

Medications used to treat some musculoskeletal disorders associated with pain, spasms, abnormal contraction, or impaired mobility.


Disorders of the musculoskeletal system are rather common. Drugs used to treat such conditions may be classified into two broad categories:

(P. 400)

1. Skeletal muscle relaxants

2. Nonsteroidal Anti-inflammatory drugs (NSAIDs)