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Blood helps maintain homeostasis by

Transport gas, nutrients, waste
Transport molecules
Transport regulatory molecules
Regulation of pH and osmosis
Body temp
Protection
Clot formation

1

Normal pH range of blood

7.35-7.45

2

Blood

Type of connective tissue consisting of a liquid matrix contains cells and cell fragments

3

Plasma and formed element percentages

55% plasma
45% formed elements
8% body weight

4

Plasma

91% water
9% other
Liquid part of blood

5

Colloid

A liquid containing suspended substances that do not settle out of solution

6

3 plasma proteins

Albumin
Globulins
Fibrinogen

7

Albumin

Maintains colloid osmotic pressure. Regulates movement of water between tissues and blood

8

Albumin transports

Fatty acids
Bilirubin
Thyroid hormones

9

Globulins

Transports substances, protection against microorganisms

10

Fibrinogen

Formation of blood clots

11

Serum

Plasma without clotting factors

12

Formed elements of blood

RBC, WBC, platelet

13

Hematopoiesis

Process of RBC production

14

Hemocytoblasts

All formed elements of blood come from this stem cell

15

Myeloid stem cell

Proeryrthroblasts, myeloblasts, mono blasts, megakaryoblasts

16

Proerythroblasts

Form RBC

17

Myeloblasts

Basophils
Eosinophils
Neutrophils

18

Monoblasts

Monocytes develop

19

Megakaryoblasts

Platelets develop

20

Colony-stimulating factors

Signal development of formed elements. Also hormones

21

Erythropoietin

Hormone secreted by endocrine cells of kidneys. Stimulates RBC production

22

Hemoglobin

Pigmented protein. 1/3 cell volume and color

23

Hemolysis

RBC rupture followed by hemoglobin release

24

Carbonic anhydrase

Enzyme in RBC. CO2 + water creates H+ and bicarbonate ions

25

Globin

Polypeptide chain. 4 in hemoglobin

26

Heme

Red-pigmented molecule with iron

27

Carbaminohemoglobin

Carbon dioxide attached to Globin molecule

28

Carb oxyhemoglobin

Carbon monoxide binds to iron of hemoglobin

29

Birth of RBC
Erythropoiesis

Hemocytoblasts
Myeloid stem cells
Proerythroblasts
Early erythroblasts
Intermediate erythroblasts
Late erythroblasts