What are Neutrophils?
Most abundant WBC
Performs phagocytosis of foreign particles
Increased numer during acute a bacterial infeciton
Describe the components of plasma?
Blood plasma is composed of 2 parts:
- Solutes (plasma proteins, nutrients, wastes, gases, electrolytes)
What does Thrombopoietin do?
Increase the number of platelet precursors
What is the function of hemoglobin?
Hemoglobin is a protein in red blood cells that carries oxygen and some carbon dioxide.
Composed of 4 globular protein chains (globin) and a heme group, centered around an Fe molecule.
What are the 3 main plasma proteins?
What is leukocytosis?
A increases in the number of white blood cells
What does Cytokines do?
Increase the number of WBC precursors.
What do Lymphoid stem cells give rise to?
Agranular lymphocytes (T and B-cells)
What are the 2 primary functions of albumin?
Maintenance of osmotic pressure
Transportation of free fatty acids, hormones, and bilirubin
Describe the antigens and antibodies involved in ABO blood type group.
Antigens A and B determine blood type.
Plasma contains antibodies designed as anti-a and anti-b that react with antigen that are foreign
What two lines of stem cells does Hemocytoblasts give rise to?
Myeloid Stem cells
Lymphoid stem cells
What are Lymphocytes?
Cells live for an extended period of time
Increase during viral and bacterial infection.
What do Myleoid stem cells give rise to?
Erythrocytes, platelets, granular leukocytes, and agranular monocytes.
What are Basophilis?
Realse Haprin and Histamine
Can develop into mast cells.
What is hemostasis?
The stoppage of bleeding
What are the three types of cells that comprise formed elements?
1. Erythrocyes (Red Blood Cells)
2. Leukocytes (White Blood Cells)
3. Thrombocytes (Platelets)
What would a decreased hematocrit indicate?
Anemia: A decrease in number of RBC
What are Neutrophils and their functions?
They are Granulocytes
Most abundant WBC
Preform phagocytosis of foreign particles
Increased number during bacterial direction.
Describe the Rh Blood group and the antigens and antibodies involved.
Rh antigen are classified as Rh+
Those who lack the antigen are Rh-
What is clotting factor II a?
List the three functions of blood.
1. Transportation of gases, nurtients,waste, and hormones
2. Regulation of pH, temp. and water
3. Protection through clotting, and combating microbes with phagocytes and plasma protein.
Describe the extrinsic pathway for blood
Initiated by tissue damage which leads to the release of Tissue thromboplastin (III)
Factors involved include VII, X, and V.
Leads to the release of Prothrombin activator.
What clotting factor is III ?
Describe the process of erythropoiesis.
Low O2 causes the kidneys and live to release erythrpoietin (EPO) into the bloodstream where it travels to red bone marrow and stimulates production of RBC that carry O2 to tissues.
What is a reticulocyte count?
A test used to indicate the rate of erythropoiesis (normal range 0.5 - 1.5%)
Abnormally high reticulocyte count suggests anemia.
What is fibrin?
The insoluble protein that leads to the actual clot.
Describe the breakdown of RBC and hemoglobin.
What are the functions of platlets?
To function to stop blood loss from damaged vessels by
forming a platelet plug.
What would a increaed hematocrit indicate?
Polycythemia: a increase in RBC, seen in atheletes that are blood doping.
What is a thrombosis?